PDF(Pubmed)
Abstract：
A 45-year-old woman on treatment for HIV infection with highly active antiretroviral therapy for the past 10 years presented to us with a history of Raynaud\'s phenomenon and hyperpigmentation of the skin for 2 years. She was diagnosed to have pulmonary arterial hypertension 8 months ago. On examination, she had salt-and-pepper pigmentation and sclerodactyly. Her biochemical workup was normal. She had positive antinuclear antibody by indirect immunofluorescence method. Skin biopsy was consistent with systemic sclerosis. HIV has its own musculoskeletal manifestations. The paradox of autoimmunity in the background of immunodeficiency was intriguing. Treating autoimmunity in the presence of immunodeficiency was challenging. The attribution and differentiation of pulmonary hypertension were difficult. There has been a homology identified between human immunodeficiency virus 1 (HIV 1) and centromere B protein (CENP B). This case is reported because of the unusual occurrence of systemic sclerosis in an HIV patient.
摘要：
一位45岁的女性在过去的10年中接受了高效抗逆转录病毒治疗的HIV感染的治疗，他有2年的雷诺现象和皮肤色素沉着过度的历史。她8个月前被诊断为肺动脉高压。在检查中，她有盐和胡椒的色素沉着和硬化。她的生化检查正常。间接免疫荧光法测得抗核抗体阳性。皮肤活检符合系统性硬化症。HIV有其自身的肌肉骨骼表现。在免疫缺陷的背景下，自身免疫的悖论很有趣。在存在免疫缺陷的情况下治疗自身免疫具有挑战性。肺动脉高压的归因和鉴别比较困难。在人类免疫缺陷病毒1(HIV1)和着丝粒B蛋白(CENPB)之间已鉴定出同源性。报告该病例是因为HIV患者中系统性硬化症的异常发生。
