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Abstract：
Quality control of programs for detection of significant prostate cancer (sPCa) could be defined by the correlation between observed and reference 95% confidence intervals (CIs) for Prostate Imaging-Reporting and Data System (PI-RADS) categories. We used the area under the receiver operating characteristic curve (AUC) for the Barcelona magnetic resonance imaging (MRI) predictive model to screen the quality of ten participant centers in the sPCa opportunistic early detection program in Catalonia. We set an AUC of <0.8 as the criterion for suboptimal quality. Quality was confirmed in terms of the correlation between actual sPCa detection rates and reference 95% CIs. For a cohort of 2624 men with prostate-specific antigen >3.0 ng/ml and/or a suspicious digital rectal examination who underwent multiparametric MRI and two- to four-core targeted biopsies of PI-RADS ≥3 lesions and/or 12-core systematic biopsy, AUC values ranged from 0.527 to 0.914 and were <0.8 in four centers (40%). There was concordance between actual sPCa detection rates and reference 95% CIs for one or two PI-RADS categories when the AUC was <0.8, and for three or four PI-RADS categories when the AUC was ≥0.8. A review of procedures used for sPCa detection should be recommended in centers with suboptimal quality.
UNASSIGNED: We tested a method for assessing quality control for centers carrying out screening for early detection of prostate cancer. We found that the method can identify centers that may need to review their procedures for detection of significant prostate cancer.
UNASSIGNED: We tested a method for assessing quality control for centers carrying out screening for early detection of prostate cancer. We found that the method can identify centers that may need to review their procedures for detection of significant prostate cancer.
摘要：
用于检测显著前列腺癌（sPCa）的程序的质量控制可以通过前列腺成像报告和数据系统（PI-RADS）类别的观察和参考95％置信区间（CI）之间的相关性来定义。我们使用巴塞罗那磁共振成像（MRI）预测模型的接收器工作特征曲线（AUC）下的面积来筛选加泰罗尼亚sPCa机会性早期检测计划中十个参与者中心的质量。我们设定<0.8的AUC作为次优质量的标准。根据实际sPCa检测率与参考95%CIs之间的相关性来确认质量。对于2624名前列腺特异性抗原>3.0ng/ml和/或可疑直肠指检的男性队列，他们接受了多参数MRI和PI-RADS≥3个病灶的2至4核心靶向活检和/或12核心系统活检，AUC值范围为0.527至0.914,并且在四个中心(40%)中<0.8。当AUC<0.8时，一个或两个PI-RADS类别的实际sPCa检测率与参考95％CIs之间存在一致性，当AUC≥0.8时，三个或四个PI-RADS类别的实际sPCa检测率与参考95％CIs之间存在一致性。应建议在质量欠佳的中心审查用于sPCa检测的程序。
■我们测试了一种评估前列腺癌早期筛查中心质量控制的方法。我们发现该方法可以识别可能需要审查其程序以检测重要前列腺癌的中心。
■我们测试了一种评估前列腺癌早期筛查中心质量控制的方法。我们发现该方法可以识别可能需要审查其程序以检测重要前列腺癌的中心。
