PDF(Pubmed)
Abstract：
UNASSIGNED: Coronavirus disease 2019 can spread rapidly. Surgery in the oral cavity poses a high risk of transmission of severe acute respiratory syndrome coronavirus 2. The American Dental Association and the Centers for Disease Control and Prevention recommend the use of mouthwash containing 1.5% hydrogen peroxide (H 2O 2) or 0.2% povidone iodine (PI) to reduce the viral load in the upper respiratory tract and decrease the risk of transmission. The aim of the present study was to analyze the effect of mouth rinsing and gargling with mouthwash containing 1% PI, 0.5% PI, 3% H 2O 2, or 1.5% H 2O 2 and water on the cycle threshold (CT) value obtained by real-time reverse transcription polymerase chain reaction (RT-PCR).
UNASSIGNED: This study is a randomized single blind controlled clinical trial which has been registered in the International Standard Randomized Controlled Trial Number (ISRCTN) registry on the 3 rd February 2022 (Registration number: ISRCTN18356379). In total, 69 subjects recruited from Persahabatan General Hospital who met the inclusion criteria were randomly assigned to one of four treatment groups or the control group. The subjects were instructed to gargle with 15 mL of mouthwash for 30 s in the oral cavity followed by 30 s in the back of the throat, three times per day for 5 days. CT values were collected on postprocedural days 1, 3, and 5.
UNASSIGNED: The results of the Friedman test significantly differed among the groups (n=15). The CT values increased from baseline (day 0) to postprocedural days 1, 3, and 5.
UNASSIGNED: Mouth rinsing and gargling with mouthwash containing 1% PI, 0.5% PI, 3% H 2O 2, or 1.5% H 2O 2 and water increased the CT value.
UNASSIGNED: This study is a randomized single blind controlled clinical trial which has been registered in the International Standard Randomized Controlled Trial Number (ISRCTN) registry on the 3 rd February 2022 (Registration number: ISRCTN18356379). In total, 69 subjects recruited from Persahabatan General Hospital who met the inclusion criteria were randomly assigned to one of four treatment groups or the control group. The subjects were instructed to gargle with 15 mL of mouthwash for 30 s in the oral cavity followed by 30 s in the back of the throat, three times per day for 5 days. CT values were collected on postprocedural days 1, 3, and 5.
UNASSIGNED: The results of the Friedman test significantly differed among the groups (n=15). The CT values increased from baseline (day 0) to postprocedural days 1, 3, and 5.
UNASSIGNED: Mouth rinsing and gargling with mouthwash containing 1% PI, 0.5% PI, 3% H 2O 2, or 1.5% H 2O 2 and water increased the CT value.
摘要：
■2019年冠状病毒病可以迅速传播。口腔手术具有传播严重急性呼吸综合征冠状病毒2的高风险。美国牙科协会和疾病控制与预防中心建议使用含1.5％过氧化氢（H2O2）或0.2％聚维酮碘（PI）的漱口水，以减少上呼吸道的病毒载量并降低传播风险。本研究的目的是分析含1％PI的漱口水漱口和漱口的效果，0.5%PI,3％H2O2，或1.5％H2O2和水的循环阈值（CT）通过实时逆转录聚合酶链反应（RT-PCR）获得。
本研究是一项随机单盲对照临床试验，已在2022年2月3日的国际标准随机对照试验编号（ISRCTN）注册（注册编号：ISRCTN18356379）。总的来说,从Perahabatan总医院招募的符合纳入标准的69名受试者被随机分配到四个治疗组或对照组之一。受试者被指示用15mL漱口水在口腔中漱口30s，然后在喉咙后部30s，每天三次，共5天。在术后第1、3和5天收集CT值。
■Friedman检验的结果在各组(n=15)之间显著不同。CT值从基线（第0天）到术后第1、3和5天增加。
■用含1%PI的漱口水漱口，0.5%PI,3％H2O2或1.5％H2O2和水增加了CT值。
本研究是一项随机单盲对照临床试验，已在2022年2月3日的国际标准随机对照试验编号（ISRCTN）注册（注册编号：ISRCTN18356379）。总的来说,从Perahabatan总医院招募的符合纳入标准的69名受试者被随机分配到四个治疗组或对照组之一。受试者被指示用15mL漱口水在口腔中漱口30s，然后在喉咙后部30s，每天三次，共5天。在术后第1、3和5天收集CT值。
■Friedman检验的结果在各组(n=15)之间显著不同。CT值从基线（第0天）到术后第1、3和5天增加。
■用含1%PI的漱口水漱口，0.5%PI,3％H2O2或1.5％H2O2和水增加了CT值。
