PDF(Pubmed)
Abstract：
Fibroblasts are cells of mesenchymal origin that are found throughout the body. While these cells have several functions, their integral roles include maintaining tissue architecture through the production of key extracellular matrix components, and participation in wound healing after injury. Fibroblasts are also key mediators in disease progression during fibrosis, cancer, and other inflammatory diseases. Under these perturbed states, fibroblasts can activate into inflammatory fibroblasts or contractile myofibroblasts. Fibroblasts require various growth factors and mitogenic molecules for survival, proliferation, and differentiation. While the activity of mitogenic growth factors on fibroblasts in vitro was characterized as early as the 1970s, the proliferation and differentiation effects of growth factors on these cells in vivo are unclear. Recent work exploring the heterogeneity of fibroblasts raises questions as to whether all fibroblast cell states exhibit the same growth factor requirements. Here, we will examine and review existing studies on the influence of fibroblast growth factor receptors (FGFRs), platelet-derived growth factor receptors (PDGFRs), and transforming growth factor β receptor (TGFβR) on fibroblast cell states.
摘要：
成纤维细胞是在整个身体中发现的间充质来源的细胞。虽然这些细胞有几个功能，它们不可或缺的作用包括通过产生关键的细胞外基质成分来维持组织结构，并参与受伤后的伤口愈合。成纤维细胞也是纤维化过程中疾病进展的关键介质，癌症,和其他炎症性疾病。在这些混乱的状态下，成纤维细胞可以激活为炎性成纤维细胞或收缩肌成纤维细胞。成纤维细胞需要各种生长因子和促有丝分裂分子才能存活，扩散,和差异化。虽然促有丝分裂生长因子在体外对成纤维细胞的活性早在20世纪70年代就被表征，生长因子在体内对这些细胞的增殖和分化作用尚不清楚。最近探索成纤维细胞异质性的工作提出了是否所有成纤维细胞状态都表现出相同的生长因子需求的问题。这里,我们将检查和回顾关于成纤维细胞生长因子受体（FGFRs）影响的现有研究，血小板衍生生长因子受体（PDGFR），和转化生长因子β受体（TGFβR）对成纤维细胞状态的影响。
