PDF(Pubmed)
Abstract：
UNASSIGNED: In this study, we used a bibliometric and visual analysis to evaluate the characteristics of the 100 most cited articles on axon regeneration.
UNASSIGNED: The 100 most cited papers on axon regeneration published between 2003 and 2023 were identified by searching the Web of Science Core Collection database. The extracted data included the title, author, keywords, journal, publication year, country, and institution. A bibliometric analysis was subsequently undertaken.
UNASSIGNED: The examined set of 100 papers collectively accumulated a total of 39,548 citations. The number of citations for each of the top 100 articles ranged from 215 to 1,604, with a median value of 326. The author with the most contributions to this collection was He, Zhigang, having authored eight papers. Most articles originated in the United States (n = 72), while Harvard University was the institution with the most cited manuscripts (n = 19). Keyword analysis unveiled several research hotspots, such as chondroitin sulfate proteoglycan, alternative activation, exosome, Schwann cells, axonal protein synthesis, electrical stimulation, therapeutic factors, and remyelination. Examination of keywords in the articles indicated that the most recent prominent keyword was \"local delivery.\"
UNASSIGNED: This study offers bibliometric insights into axon regeneration, underscoring that the United States is a prominent leader in this field. Our analysis highlights the growing relevance of local delivery systems in axon regeneration. Although these systems have shown promise in preclinical models, challenges associated with long-term optimization, agent selection, and clinical translation remain. Nevertheless, the continued development of local delivery technologies represents a promising pathway for achieving axon regeneration; however, additional research is essential to fully realize their potential and thereby enhance patient outcomes.
UNASSIGNED: The 100 most cited papers on axon regeneration published between 2003 and 2023 were identified by searching the Web of Science Core Collection database. The extracted data included the title, author, keywords, journal, publication year, country, and institution. A bibliometric analysis was subsequently undertaken.
UNASSIGNED: The examined set of 100 papers collectively accumulated a total of 39,548 citations. The number of citations for each of the top 100 articles ranged from 215 to 1,604, with a median value of 326. The author with the most contributions to this collection was He, Zhigang, having authored eight papers. Most articles originated in the United States (n = 72), while Harvard University was the institution with the most cited manuscripts (n = 19). Keyword analysis unveiled several research hotspots, such as chondroitin sulfate proteoglycan, alternative activation, exosome, Schwann cells, axonal protein synthesis, electrical stimulation, therapeutic factors, and remyelination. Examination of keywords in the articles indicated that the most recent prominent keyword was \"local delivery.\"
UNASSIGNED: This study offers bibliometric insights into axon regeneration, underscoring that the United States is a prominent leader in this field. Our analysis highlights the growing relevance of local delivery systems in axon regeneration. Although these systems have shown promise in preclinical models, challenges associated with long-term optimization, agent selection, and clinical translation remain. Nevertheless, the continued development of local delivery technologies represents a promising pathway for achieving axon regeneration; however, additional research is essential to fully realize their potential and thereby enhance patient outcomes.
摘要：
■在这项研究中，我们使用文献计量和视觉分析来评估100篇被引用最多的轴突再生文章的特征。
■通过搜索WebofScienceCoreCollection数据库，确定了2003年至2023年之间发表的有关轴突再生的100篇引用最多的论文。提取的数据包括标题，作者,关键词,journal,出版年份,国家,和机构。随后进行了文献计量分析。
■接受审查的100篇论文总共积累了39,548篇引文。排名前100位的每篇文章的引用次数从215到1,604不等，中位数为326。对这个系列贡献最大的作者是他，志刚,撰写了八篇论文。大多数文章起源于美国(n=72)，而哈佛大学是被引用手稿最多的机构（n=19）。关键词分析揭示了几个研究热点，如硫酸软骨素蛋白聚糖，替代激活，exosome,施万细胞，轴突蛋白质合成，电刺激,治疗因素,和髓鞘再生。对文章中关键字的检查表明，最近的突出关键字是“本地交付”。\"
■这项研究提供了轴突再生的文献计量学见解，强调美国是这一领域的杰出领导者。我们的分析强调了轴突再生中本地输送系统的相关性。尽管这些系统在临床前模型中显示出了希望，与长期优化相关的挑战，代理选择，和临床翻译仍然存在。然而，本地递送技术的持续发展代表了实现轴突再生的有希望的途径;然而,额外的研究对于充分发挥它们的潜力，从而提高患者的治疗效果至关重要。
■通过搜索WebofScienceCoreCollection数据库，确定了2003年至2023年之间发表的有关轴突再生的100篇引用最多的论文。提取的数据包括标题，作者,关键词,journal,出版年份,国家,和机构。随后进行了文献计量分析。
■接受审查的100篇论文总共积累了39,548篇引文。排名前100位的每篇文章的引用次数从215到1,604不等，中位数为326。对这个系列贡献最大的作者是他，志刚,撰写了八篇论文。大多数文章起源于美国(n=72)，而哈佛大学是被引用手稿最多的机构（n=19）。关键词分析揭示了几个研究热点，如硫酸软骨素蛋白聚糖，替代激活，exosome,施万细胞，轴突蛋白质合成，电刺激,治疗因素,和髓鞘再生。对文章中关键字的检查表明，最近的突出关键字是“本地交付”。\"
■这项研究提供了轴突再生的文献计量学见解，强调美国是这一领域的杰出领导者。我们的分析强调了轴突再生中本地输送系统的相关性。尽管这些系统在临床前模型中显示出了希望，与长期优化相关的挑战，代理选择，和临床翻译仍然存在。然而，本地递送技术的持续发展代表了实现轴突再生的有希望的途径;然而,额外的研究对于充分发挥它们的潜力，从而提高患者的治疗效果至关重要。
