Abstract：
Identifying macular neovascularization (MNV) in eyes with central serous chorioretinopathy (CSC) has important implications for its management. Optical coherence tomography angiography (OCTA) is increasingly used for this purpose. Here, we systematically reviewed the literature and conducted meta-analysis to determine the diagnostic accuracy of OCTA for detecting MNV in eyes with CSC. We systematically searched the literature in 12 databases for relevant studies from database inception until 18 November 2023. Eligible studies had eyes with CSC with MNV and CSC without MNV. Index test was OCTA. Reference test was retinal dye angiography. Study selection and data extraction were performed in duplicate, and study was evaluated using the Quality Assessment of Diagnostic Accuracy Studies 2. Our main outcome of interest was the sensitivity and specificity of OCTA for detecting MNV in CSC. Pooled diagnostic test accuracy estimates were computed using MetaDTA. Of 177 records screened, seven fulfilled the eligibility criteria for our study. These studies summarized data from a total of 1061 eyes. Summary estimate sensitivity and specificity to diagnose MNV in eyes with CSC using OCTA was 92.9% (95% CI: 81.7%-97.5%) and 99.4% (95% CI: 84.1%-100.0%), respectively. The main source of bias across studies was the reference standard, as four studies used multimodal imaging including OCTA for the reference standard. OCTA alone is excellent for detecting MNV in CSC compared to retinal dye angiography or multimodal imaging. Using OCTA first before considering retinal dye angiography could potentially save an important number of retinal dye angiographies.
摘要：
在患有中心性浆液性脉络膜视网膜病变（CSC）的眼中识别黄斑新生血管（MNV）对其治疗具有重要意义。光学相干断层扫描血管造影（OCTA）越来越多地用于此目的。这里,我们系统回顾了文献并进行了荟萃分析,以确定OCTA在CSC患者眼中检测MNV的诊断准确性.从数据库开始到2023年11月18日，我们系统地搜索了12个数据库中的相关研究文献。符合条件的研究有具有MNV的CSC和没有MNV的CSC的眼睛。指数测试为OCTA。参考测试为视网膜染料血管造影。研究选择和数据提取一式两份，使用诊断准确性研究2的质量评估对研究进行了评估。我们感兴趣的主要结果是OCTA检测CSC中MNV的敏感性和特异性。使用MetaDTA计算汇总诊断测试准确性估计值。在筛选的177条记录中，7人符合我们研究的资格标准.这些研究总结了总共1061只眼睛的数据。使用OCTA诊断CSC眼中MNV的汇总估计敏感性和特异性为92.9％（95％CI：81.7％-97.5％）和99.4％（95％CI：84.1％-100.0％），分别。研究中偏倚的主要来源是参考标准，因为4项研究使用包括OCTA在内的多模态成像作为参考标准.与视网膜染料血管造影或多模态成像相比,单独的OCTA对于检测CSC中的MNV是优异的。在考虑视网膜染料血管造影术之前首先使用OCTA可能会节省大量的视网膜染料血管造影术。
