Abstract：
Proteases are implicated in every hallmark of cancer and have complicated functions. For cancer cells to survive and thrive, the process of controlling intracellular proteins to keep the balance of the cell proteome is essential. Numerous natural compounds have been used as ligands/ small molecules to target various proteases that are found in the lysosomes, mitochondria, cytoplasm, and extracellular matrix, as possible anticancer therapeutics. Promising protease modulators have been developed for new drug discovery technology through recent breakthroughs in structural and chemical biology. The protein structure, function of significant tumor-related proteases, and their natural compound inhibitors have been briefly included in this study. This review highlights the most current frontiers and future perspectives for novel therapeutic approaches associated with the list of anticancer natural compounds targeting protease and the mode and mechanism of proteinase-mediated molecular pathways in cancer.
摘要：
蛋白酶与癌症的每个标志有关，并且具有复杂的功能。为了让癌细胞存活和茁壮成长，控制细胞内蛋白质以保持细胞蛋白质组平衡的过程是必不可少的。许多天然化合物已被用作配体/小分子以靶向溶酶体中发现的各种蛋白酶。线粒体,细胞质，和细胞外基质，作为可能的抗癌疗法。通过最近在结构和化学生物学方面的突破,已经为新的药物发现技术开发了有前景的蛋白酶调节剂。蛋白质结构，重要的肿瘤相关蛋白酶的功能，和他们的天然化合物抑制剂已被简要包括在这项研究中。这篇综述强调了与靶向蛋白酶的抗癌天然化合物列表以及蛋白酶介导的癌症分子途径的模式和机制相关的新型治疗方法的最新前沿和未来前景。
