Abstract：
OBJECTIVE: To investigate the independent and combined effects of physical activity (PA) and depressive symptoms on the risk of frailty in community-dwelling older adults.
BACKGROUND: Older adults face a high risk of frailty which is commonly used to predict adverse health outcomes in older patients. Engaging in PA and without depressive symptoms are crucial factors to prevent frailty. It is essential to investigate the independent and combined effects of these two variables on the risk of frailty.
METHODS: We included 3392 community-dwelling older adults. The FRAIL Scale was used to assess older adults\' frail status (robust, prefrail and frail). Multiple logistic regression was utilized to examine the independent and combined effects of PA and depressive symptoms on the risk of prefrailty and frailty. The combined effects were visualized by marginal plots.
RESULTS: The prevalence of prefrailty and frailty in older adults were 42.16% and 10.58%. Compared with the group of \"Light physical activity and With depressive symptoms\", \"Vigorous physical activity and Without depressive symptoms\" had the lowest risk of prefrailty and frailty.
CONCLUSIONS: Older adults who do not engage in PA or have depressive symptoms increased the risk of frailty, but older adults with depressive symptoms could lower the risk of frailty through PA.
CONCLUSIONS: It is effective to reduce the risk of frailty by directing older adults to do moderate physical activity, although they have depressive symptoms. The focus should also be on older adults with depressive symptoms, who have at least more than twice and fourfold risk of prefrailty and frailty compared to those without.
CONCLUSIONS: This study offers insights for future interventions aimed at preventing frailty in older adults.
UNASSIGNED: This study adhered to the STROBE checklist.
UNASSIGNED: Older adults participated in this study and completed questionnaires.
BACKGROUND: Older adults face a high risk of frailty which is commonly used to predict adverse health outcomes in older patients. Engaging in PA and without depressive symptoms are crucial factors to prevent frailty. It is essential to investigate the independent and combined effects of these two variables on the risk of frailty.
METHODS: We included 3392 community-dwelling older adults. The FRAIL Scale was used to assess older adults\' frail status (robust, prefrail and frail). Multiple logistic regression was utilized to examine the independent and combined effects of PA and depressive symptoms on the risk of prefrailty and frailty. The combined effects were visualized by marginal plots.
RESULTS: The prevalence of prefrailty and frailty in older adults were 42.16% and 10.58%. Compared with the group of \"Light physical activity and With depressive symptoms\", \"Vigorous physical activity and Without depressive symptoms\" had the lowest risk of prefrailty and frailty.
CONCLUSIONS: Older adults who do not engage in PA or have depressive symptoms increased the risk of frailty, but older adults with depressive symptoms could lower the risk of frailty through PA.
CONCLUSIONS: It is effective to reduce the risk of frailty by directing older adults to do moderate physical activity, although they have depressive symptoms. The focus should also be on older adults with depressive symptoms, who have at least more than twice and fourfold risk of prefrailty and frailty compared to those without.
CONCLUSIONS: This study offers insights for future interventions aimed at preventing frailty in older adults.
UNASSIGNED: This study adhered to the STROBE checklist.
UNASSIGNED: Older adults participated in this study and completed questionnaires.
摘要：
目的：调查体力活动（PA）和抑郁症状对社区居住老年人体弱风险的独立和综合影响。
背景：老年人面临很高的虚弱风险，这通常用于预测老年患者的不良健康结局。参与PA和没有抑郁症状是预防虚弱的关键因素。必须研究这两个变量对虚弱风险的独立和综合影响。
方法：我们纳入了3392名社区居住的老年人。FRAIL量表用于评估老年人的虚弱状态(稳健，prefrail和脆弱)。采用多元逻辑回归分析PA和抑郁症状对早弱和虚弱风险的独立和综合影响。组合效果通过边缘图可视化。
结果：老年人早弱和虚弱的患病率分别为42.16%和10.58%。与“轻度体力活动和抑郁症状”组相比，“剧烈的体力活动和没有抑郁症状”的脆弱和虚弱风险最低。
结论：不参与PA或有抑郁症状的老年人增加了虚弱的风险，但是有抑郁症状的老年人可以通过PA降低虚弱的风险。
结论：指导老年人进行适度的体育锻炼可有效降低虚弱风险，尽管他们有抑郁症状.重点还应该放在有抑郁症状的老年人身上，与没有的人相比，他们至少有两倍和四倍以上的脆弱和脆弱风险。
结论：这项研究为未来旨在预防老年人虚弱的干预措施提供了见解。
■这项研究遵循了STROBE检查表。
■老年人参加了这项研究并完成了问卷调查。
背景：老年人面临很高的虚弱风险，这通常用于预测老年患者的不良健康结局。参与PA和没有抑郁症状是预防虚弱的关键因素。必须研究这两个变量对虚弱风险的独立和综合影响。
方法：我们纳入了3392名社区居住的老年人。FRAIL量表用于评估老年人的虚弱状态(稳健，prefrail和脆弱)。采用多元逻辑回归分析PA和抑郁症状对早弱和虚弱风险的独立和综合影响。组合效果通过边缘图可视化。
结果：老年人早弱和虚弱的患病率分别为42.16%和10.58%。与“轻度体力活动和抑郁症状”组相比，“剧烈的体力活动和没有抑郁症状”的脆弱和虚弱风险最低。
结论：不参与PA或有抑郁症状的老年人增加了虚弱的风险，但是有抑郁症状的老年人可以通过PA降低虚弱的风险。
结论：指导老年人进行适度的体育锻炼可有效降低虚弱风险，尽管他们有抑郁症状.重点还应该放在有抑郁症状的老年人身上，与没有的人相比，他们至少有两倍和四倍以上的脆弱和脆弱风险。
结论：这项研究为未来旨在预防老年人虚弱的干预措施提供了见解。
■这项研究遵循了STROBE检查表。
■老年人参加了这项研究并完成了问卷调查。
