Abstract：
UNASSIGNED: Little attention has been given to prenatal cobalamin insufficiency in settings where dietary cobalamin intake is presumed adequate, such as populations with habitual intake of foods from animal sources.
UNASSIGNED: However, low cobalamin status in women of fertile age has been reported in Europe, United States, and Canada. In India, where cobalamin deficiency is highly prevalent, it has been associated with an increased risk of miscarriage, intrauterine growth retardation, as well as insulin resistance and lower neurodevelopment scores in the offspring. Low cobalamin status in pregnancy has been associated with similar outcomes as those reported in the Indian studies although the evidence is scant and conflicting.
UNASSIGNED: Consideration should be given to maternal cobalamin status in the context of prevention of adverse pregnancy outcomes as well as cobalamin insufficiency both in the mother and the offspring during lactation. Further attention is now justified with the increasing tendency toward plant-based diets. Reference intervals for cobalamin status during each trimester of pregnancy are needed and further investigation of the long-term conse-quences of low cobalamin status during pregnancy for health and development in the offspring is warranted.
Plain language titleInadequate cobalamin status during critical periods of growth and development can have negative consequences on maternal and childhood health.
UNASSIGNED: However, low cobalamin status in women of fertile age has been reported in Europe, United States, and Canada. In India, where cobalamin deficiency is highly prevalent, it has been associated with an increased risk of miscarriage, intrauterine growth retardation, as well as insulin resistance and lower neurodevelopment scores in the offspring. Low cobalamin status in pregnancy has been associated with similar outcomes as those reported in the Indian studies although the evidence is scant and conflicting.
UNASSIGNED: Consideration should be given to maternal cobalamin status in the context of prevention of adverse pregnancy outcomes as well as cobalamin insufficiency both in the mother and the offspring during lactation. Further attention is now justified with the increasing tendency toward plant-based diets. Reference intervals for cobalamin status during each trimester of pregnancy are needed and further investigation of the long-term conse-quences of low cobalamin status during pregnancy for health and development in the offspring is warranted.
Plain language titleInadequate cobalamin status during critical periods of growth and development can have negative consequences on maternal and childhood health.
摘要：
■在假定膳食钴胺摄入充足的环境中，对产前钴胺不足的关注很少，例如习惯性地从动物来源摄取食物的人群。
■然而，在欧洲，有报道称育龄妇女的钴胺水平较低，美国,和加拿大。在印度,钴胺缺乏症非常普遍，它与流产风险增加有关，宫内发育迟缓,以及胰岛素抵抗和后代神经发育得分较低。尽管证据很少且相互矛盾，但妊娠中的低钴胺状态与印度研究报告的结果相似。
在预防不良妊娠结局以及哺乳期母亲和后代的钴胺不足时，应考虑母体的钴胺状况。现在，随着植物性饮食的趋势日益增加，进一步的关注是合理的。需要在怀孕的每个三个月中对钴胺素状态进行参考间隔，并且有必要进一步调查怀孕期间低钴胺素状态的长期后果，以促进后代的健康和发育。
简单的语言标题在生长发育的关键时期钴胺状态不足会对母亲和儿童的健康产生负面影响。
■然而，在欧洲，有报道称育龄妇女的钴胺水平较低，美国,和加拿大。在印度,钴胺缺乏症非常普遍，它与流产风险增加有关，宫内发育迟缓,以及胰岛素抵抗和后代神经发育得分较低。尽管证据很少且相互矛盾，但妊娠中的低钴胺状态与印度研究报告的结果相似。
在预防不良妊娠结局以及哺乳期母亲和后代的钴胺不足时，应考虑母体的钴胺状况。现在，随着植物性饮食的趋势日益增加，进一步的关注是合理的。需要在怀孕的每个三个月中对钴胺素状态进行参考间隔，并且有必要进一步调查怀孕期间低钴胺素状态的长期后果，以促进后代的健康和发育。
简单的语言标题在生长发育的关键时期钴胺状态不足会对母亲和儿童的健康产生负面影响。
