Abstract：
BACKGROUND: Postoperative pulmonary complications (PPCs) vary amongst different surgical techniques. We aim to compare the incidence of PPCs after laparoscopic non-robotic versus laparoscopic robotic abdominal surgery.
METHODS: LapRas (Risk Factors for PPCs in Laparoscopic Non-robotic vs Laparoscopic robotic abdominal surgery) incorporates harmonized data from 2 observational studies on abdominal surgery patients and PPCs: \'Local ASsessment of VEntilatory management during General Anaesthesia for Surgery\' (LAS VEGAS), and \'Assessment of Ventilation during general AnesThesia for Robotic surgery\' (AVATaR). The primary endpoint is the occurrence of one or more PPCs in the first five postoperative days. Secondary endpoints include the occurrence of each individual PPC, hospital length of stay and in-hospital mortality. Logistic regression models will be used to identify risk factors for PPCs in laparoscopic non-robotic versus laparoscopic robotic abdominal surgery. We will investigate whether differences in the occurrence of PPCs between the two groups are driven by differences in duration of anesthesia and/or the intensity of mechanical ventilation.
BACKGROUND: This analysis will address a clinically relevant research question comparing laparoscopic and robotic assisted surgery. No additional ethical committee approval is required for this metanalysis. Data will be shared with the scientific community by abstracts and original articles submitted to peer-reviewed journals.
BACKGROUND: The registration of this post-hoc analysis is pending; individual studies that were merged into the used database were registered at clinicaltrials.gov: LAS VEGAS with identifier NCT01601223, AVATaR with identifier NCT02989415.
METHODS: LapRas (Risk Factors for PPCs in Laparoscopic Non-robotic vs Laparoscopic robotic abdominal surgery) incorporates harmonized data from 2 observational studies on abdominal surgery patients and PPCs: \'Local ASsessment of VEntilatory management during General Anaesthesia for Surgery\' (LAS VEGAS), and \'Assessment of Ventilation during general AnesThesia for Robotic surgery\' (AVATaR). The primary endpoint is the occurrence of one or more PPCs in the first five postoperative days. Secondary endpoints include the occurrence of each individual PPC, hospital length of stay and in-hospital mortality. Logistic regression models will be used to identify risk factors for PPCs in laparoscopic non-robotic versus laparoscopic robotic abdominal surgery. We will investigate whether differences in the occurrence of PPCs between the two groups are driven by differences in duration of anesthesia and/or the intensity of mechanical ventilation.
BACKGROUND: This analysis will address a clinically relevant research question comparing laparoscopic and robotic assisted surgery. No additional ethical committee approval is required for this metanalysis. Data will be shared with the scientific community by abstracts and original articles submitted to peer-reviewed journals.
BACKGROUND: The registration of this post-hoc analysis is pending; individual studies that were merged into the used database were registered at clinicaltrials.gov: LAS VEGAS with identifier NCT01601223, AVATaR with identifier NCT02989415.
摘要：
背景：手术后肺部并发症（PPC）因不同的手术技术而异。我们旨在比较腹腔镜非机器人与腹腔镜机器人腹部手术后PPC的发生率。
方法：LapRas（腹腔镜非机器人与腹腔镜机器人腹部手术中PPCs的危险因素）结合了来自2项关于腹部手术患者和PPCs的观察性研究的统一数据：“全身麻醉手术期间VEntitlatory管理的局部评估”（LASVEGAS），和“机器人手术全身麻醉期间的通气评估”（AVATaR）。主要终点是在术后前五天出现一个或多个PPC。次要终点包括每个PPC的发生，住院时间和住院死亡率。Logistic回归模型将用于确定腹腔镜非机器人与腹腔镜机器人腹部手术中PPC的危险因素。我们将调查两组之间PPC发生率的差异是否由麻醉持续时间和/或机械通气强度的差异驱动。
背景：该分析将解决比较腹腔镜和机器人辅助手术的临床相关研究问题。此元分析不需要额外的道德委员会批准。数据将通过提交给同行评审期刊的摘要和原始文章与科学界共享。
背景：此事后分析的注册正在等待中；合并到已使用数据库中的个别研究已在clinicaltrials.gov：LASVEGAS上注册，标识符为NCT01601223，标识符为NCT02989415。
方法：LapRas（腹腔镜非机器人与腹腔镜机器人腹部手术中PPCs的危险因素）结合了来自2项关于腹部手术患者和PPCs的观察性研究的统一数据：“全身麻醉手术期间VEntitlatory管理的局部评估”（LASVEGAS），和“机器人手术全身麻醉期间的通气评估”（AVATaR）。主要终点是在术后前五天出现一个或多个PPC。次要终点包括每个PPC的发生，住院时间和住院死亡率。Logistic回归模型将用于确定腹腔镜非机器人与腹腔镜机器人腹部手术中PPC的危险因素。我们将调查两组之间PPC发生率的差异是否由麻醉持续时间和/或机械通气强度的差异驱动。
背景：该分析将解决比较腹腔镜和机器人辅助手术的临床相关研究问题。此元分析不需要额外的道德委员会批准。数据将通过提交给同行评审期刊的摘要和原始文章与科学界共享。
背景：此事后分析的注册正在等待中；合并到已使用数据库中的个别研究已在clinicaltrials.gov：LASVEGAS上注册，标识符为NCT01601223，标识符为NCT02989415。
