PDF(Pubmed)
Abstract：
The cleavage and polyadenylation specificity factor (CPSF) complex plays a central role in the formation of mRNA 3\' ends, being responsible for the recognition of the poly(A) signal sequence, the endonucleolytic cleavage step, and recruitment of poly(A) polymerase. CPSF has been extensively studied for over three decades, and its functions and those of its individual subunits are becoming increasingly well-defined, with much current research focusing on the impact of these proteins on the normal functioning or disease/stress states of cells. In this review, we provide an overview of the general functions of CPSF and its subunits, followed by a discussion of how they exert their functions in a surprisingly diverse variety of biological processes and cellular conditions. These include transcription termination, small RNA processing, and R-loop prevention/resolution, as well as more generally cancer, differentiation/development, and infection/immunity.
摘要：
裂解和聚腺苷酸化特异性因子（CPSF）复合物在mRNA3'末端的形成中起着核心作用，负责识别poly(A)信号序列，核酸内切切割步骤，和聚(A)聚合酶的募集。CPSF已经被广泛研究了三十多年，其功能及其各个亚基的功能越来越明确，目前的许多研究都集中在这些蛋白质对细胞正常功能或疾病/应激状态的影响上。在这次审查中,我们概述了CPSF及其子单元的一般功能，随后讨论了它们如何在令人惊讶的各种生物过程和细胞条件下发挥其功能。这些包括转录终止，小RNA处理和R环预防/解决，以及更普遍的癌症，分化/发育和感染/免疫。
