Abstract：
OBJECTIVE: Despite prior attempts to evaluate the effects of sarcopenia on survival among patients with colorectal cancer (CRC), the results of these studies have not been consistent. The present study aimed to evaluate the association between sarcopenia and survival among patients having CRC without distant metastasis by aggregating multiple studies.
METHODS: We performed a literature search using computerized databases and identified additional studies from among the bibliographies of retrieved articles. The quality of each study was evaluated using the Newcastle-Ottawa Scale, and meta-analyses were performed to evaluate overall survival (OS) and disease-free survival (DFS).
RESULTS: Thirteen studies with up to 6600 participants were included in the meta-analyses, with a mean age of 63.6 years (range: 18-93 years). We found that preoperative sarcopenia was associated with worse OS (hazard ratio [HR]: 1.61; 95% confidence interval [CI]: 1.38-1.88) and worse DFS (HR: 1.57; 95% CI: 1.10-2.24). Compared with patients without sarcopenia after tumor resection, those with postoperative sarcopenia had worse OS (HR: 1.76; 95% CI: 1.47-2.10) and DFS (HR: 1.79; 95% CI: 1.46-2.20).
CONCLUSIONS: These meta-analyses suggest that sarcopenia, no matter observed before or after tumor resection, is associated with worse OS and DFS in patients with CRC who have no distant metastasis.
METHODS: We performed a literature search using computerized databases and identified additional studies from among the bibliographies of retrieved articles. The quality of each study was evaluated using the Newcastle-Ottawa Scale, and meta-analyses were performed to evaluate overall survival (OS) and disease-free survival (DFS).
RESULTS: Thirteen studies with up to 6600 participants were included in the meta-analyses, with a mean age of 63.6 years (range: 18-93 years). We found that preoperative sarcopenia was associated with worse OS (hazard ratio [HR]: 1.61; 95% confidence interval [CI]: 1.38-1.88) and worse DFS (HR: 1.57; 95% CI: 1.10-2.24). Compared with patients without sarcopenia after tumor resection, those with postoperative sarcopenia had worse OS (HR: 1.76; 95% CI: 1.47-2.10) and DFS (HR: 1.79; 95% CI: 1.46-2.20).
CONCLUSIONS: These meta-analyses suggest that sarcopenia, no matter observed before or after tumor resection, is associated with worse OS and DFS in patients with CRC who have no distant metastasis.
摘要：
目的：尽管先前曾尝试评估少肌症对大肠癌（CRC）患者生存率的影响，这些研究的结果并不一致.本研究旨在通过汇总多项研究来评估无远处转移的CRC患者中肌肉减少症与生存率之间的关系。
方法：我们使用计算机数据库进行了文献检索，并从检索到的文献目录中确定了其他研究。使用纽卡斯尔-渥太华量表评估每项研究的质量，进行meta分析以评估总生存期(OS)和无病生存期(DFS).
结果：meta分析中纳入了13项研究，有多达6600名参与者，平均年龄63.6岁（范围：18-93岁）。我们发现术前肌肉减少症与OS较差（风险比[HR]：1.61；95％置信区间[CI]：1.38-1.88）和DFS较差（HR：1.57；95％CI：1.10-2.24）相关。与肿瘤切除后无肌肉减少症的患者相比，术后肌肉减少症患者的OS(HR:1.76;95%CI:1.47-2.10)和DFS(HR:1.79;95%CI:1.46-2.20)较差.
结论：这些荟萃分析表明，无论在肿瘤切除之前或之后观察到，在没有远处转移的CRC患者中，与OS和DFS恶化相关。
方法：我们使用计算机数据库进行了文献检索，并从检索到的文献目录中确定了其他研究。使用纽卡斯尔-渥太华量表评估每项研究的质量，进行meta分析以评估总生存期(OS)和无病生存期(DFS).
结果：meta分析中纳入了13项研究，有多达6600名参与者，平均年龄63.6岁（范围：18-93岁）。我们发现术前肌肉减少症与OS较差（风险比[HR]：1.61；95％置信区间[CI]：1.38-1.88）和DFS较差（HR：1.57；95％CI：1.10-2.24）相关。与肿瘤切除后无肌肉减少症的患者相比，术后肌肉减少症患者的OS(HR:1.76;95%CI:1.47-2.10)和DFS(HR:1.79;95%CI:1.46-2.20)较差.
结论：这些荟萃分析表明，无论在肿瘤切除之前或之后观察到，在没有远处转移的CRC患者中，与OS和DFS恶化相关。
