METHODS: We performed a literature search using computerized databases and identified additional studies from among the bibliographies of retrieved articles. The quality of each study was evaluated using the Newcastle-Ottawa Scale, and meta-analyses were performed to evaluate overall survival (OS) and disease-free survival (DFS).
RESULTS: Thirteen studies with up to 6600 participants were included in the meta-analyses, with a mean age of 63.6 years (range: 18-93 years). We found that preoperative sarcopenia was associated with worse OS (hazard ratio [HR]: 1.61; 95% confidence interval [CI]: 1.38-1.88) and worse DFS (HR: 1.57; 95% CI: 1.10-2.24). Compared with patients without sarcopenia after tumor resection, those with postoperative sarcopenia had worse OS (HR: 1.76; 95% CI: 1.47-2.10) and DFS (HR: 1.79; 95% CI: 1.46-2.20).
CONCLUSIONS: These meta-analyses suggest that sarcopenia, no matter observed before or after tumor resection, is associated with worse OS and DFS in patients with CRC who have no distant metastasis.
方法:我们使用计算机数据库进行了文献检索,并从检索到的文献目录中确定了其他研究。使用纽卡斯尔-渥太华量表评估每项研究的质量,进行meta分析以评估总生存期(OS)和无病生存期(DFS).
结果:meta分析中纳入了13项研究,有多达6600名参与者,平均年龄63.6岁(范围:18-93岁)。我们发现术前肌肉减少症与OS较差(风险比[HR]:1.61;95%置信区间[CI]:1.38-1.88)和DFS较差(HR:1.57;95%CI:1.10-2.24)相关。与肿瘤切除后无肌肉减少症的患者相比,术后肌肉减少症患者的OS(HR:1.76;95%CI:1.47-2.10)和DFS(HR:1.79;95%CI:1.46-2.20)较差.
结论:这些荟萃分析表明,无论在肿瘤切除之前或之后观察到,在没有远处转移的CRC患者中,与OS和DFS恶化相关。