PDF(Pubmed)
Abstract：
Antibodies are powerful modulators of ongoing and future B cell responses. While the concept of antibody feedback has been appreciated for over a century, the topic has seen a surge in interest due to the evidence that the broadening of antibody responses to SARS-CoV-2 after a third mRNA vaccination is a consequence of antibody feedback. Moreover, the discovery that slow antigen delivery can lead to more robust humoral immunity has put a spotlight on the capacity for early antibodies to augment B cell responses. Here, we review the mechanisms whereby antibody feedback shapes B cell responses, integrating findings in humans and in mouse models. We consider the major influence of epitope masking and the diverse actions of complement and Fc receptors and provide a framework for conceptualizing the ways antigen-specific antibodies may influence B cell responses to any form of antigen, in conditions as diverse as infectious disease, autoimmunity, and cancer.
摘要：
抗体是正在进行的和未来的B细胞反应的强大调节剂。虽然抗体反馈的概念已经被人们认识了一个多世纪，由于有证据表明第三次mRNA接种后对SARS-CoV-2的抗体应答的扩大是抗体反馈的结果，因此该主题的兴趣激增。此外，缓慢的抗原递送可以导致更强大的体液免疫这一发现引起了人们对早期抗体增强B细胞应答能力的关注.这里,我们回顾了抗体反馈形成B细胞反应的机制，整合人类和小鼠模型的发现。我们考虑了表位掩蔽的主要影响以及补体和Fc受体的不同作用，并为概念化抗原特异性抗体可能影响B细胞对任何形式抗原的反应的方式提供了框架。在传染病等不同的条件下，自身免疫,和癌症。
