{Reference Type}: Journal Article
{Title}: Antibody modulation of B cell responses-Incorporating positive and negative feedback.
{Author}: Cyster JG;Wilson PC;
{Journal}: Immunity
{Volume}: 57
{Issue}: 7
{Year}: 2024 Jul 9
{Factor}: 43.474
{DOI}: 10.1016/j.immuni.2024.06.009
{Abstract}: Antibodies are powerful modulators of ongoing and future B cell responses. While the concept of antibody feedback has been appreciated for over a century, the topic has seen a surge in interest due to the evidence that the broadening of antibody responses to SARS-CoV-2 after a third mRNA vaccination is a consequence of antibody feedback. Moreover, the discovery that slow antigen delivery can lead to more robust humoral immunity has put a spotlight on the capacity for early antibodies to augment B cell responses. Here, we review the mechanisms whereby antibody feedback shapes B cell responses, integrating findings in humans and in mouse models. We consider the major influence of epitope masking and the diverse actions of complement and Fc receptors and provide a framework for conceptualizing the ways antigen-specific antibodies may influence B cell responses to any form of antigen, in conditions as diverse as infectious disease, autoimmunity, and cancer.