Abstract：
The association of tertiary lymphoid structures (TLSs) with survival and immunotherapy response brought B cells to center stage. In a pan-cancer B cells atlas in Science, Ma et al. show that germinal center reaction generating anti-tumor antibody-secreting cells (ASCs) from B memory cells in mature TLSs co-exist in tumors with extra-follicular reaction generating auto-reactive ASCs from memory B cells in immature TLSs.
摘要：
三级淋巴结构（TLS）与存活和免疫疗法反应的关联使B细胞处于中心阶段。在《科学》杂志的泛癌症B细胞图谱中，Maetal.表明成熟TLS中B记忆细胞产生抗肿瘤抗体分泌细胞（ASC）的生发中心反应与未成熟TLS中记忆B细胞产生自反应性ASC的卵泡外反应共存于肿瘤中。
