Abstract：
OBJECTIVE: Do the various forms of hormonal and non-hormonal contraceptives have any association with ovarian stimulation outcomes, such as oocyte yield and maturation, in patients undergoing planned oocyte cryopreservation (POC)?
METHODS: This retrospective cohort study included all patients who underwent POC cycles between 2011 and 2023. The use of types of contraception before a POC cycle was recorded. The study evaluated the median number of cumulus-oocyte complexes obtained after vaginal oocyte retrieval and the proportion of metaphase II oocytes that underwent vitrification among all the cohorts.
RESULTS: A total of 4059 oocyte freezing cycles were included in the analysis. Eight types of contraceptive method were recognized in patients undergoing ovarian stimulation: intrauterine device (IUD), copper (n = 84); IUD, levonorgestrel low dose (<52 mg) (n = 37); IUD, levonorgestrel (n = 192); subdermal etonogestrel implant (n = 14); injectable medroxyprogesterone acetate (n = 11); etonogestrel vaginal ring (n = 142); combined oral contraceptive pills (n = 2349); and norelgestromin transdermal patch (n = 10). The control group included patients not using contraceptives or using barrier or calendar methods (n = 1220). Among all the cohorts the median number of cumulus-oocyte complexes retrieved during oocyte retrieval was comparable (P = 0.054), and a significant difference in oocyte maturity rate with median number of vitrified oocytes was found (P = 0.03, P < 0.001, respectively). After adjusting for confounders a multivariate analysis found no association between the type of contraceptive and proportion of metaphase II oocytes available for cryopreservation.
CONCLUSIONS: Among the various forms of contraception, none was shown to have an adverse association with oocyte yield or maturation rate in patients undergoing POC.
METHODS: This retrospective cohort study included all patients who underwent POC cycles between 2011 and 2023. The use of types of contraception before a POC cycle was recorded. The study evaluated the median number of cumulus-oocyte complexes obtained after vaginal oocyte retrieval and the proportion of metaphase II oocytes that underwent vitrification among all the cohorts.
RESULTS: A total of 4059 oocyte freezing cycles were included in the analysis. Eight types of contraceptive method were recognized in patients undergoing ovarian stimulation: intrauterine device (IUD), copper (n = 84); IUD, levonorgestrel low dose (<52 mg) (n = 37); IUD, levonorgestrel (n = 192); subdermal etonogestrel implant (n = 14); injectable medroxyprogesterone acetate (n = 11); etonogestrel vaginal ring (n = 142); combined oral contraceptive pills (n = 2349); and norelgestromin transdermal patch (n = 10). The control group included patients not using contraceptives or using barrier or calendar methods (n = 1220). Among all the cohorts the median number of cumulus-oocyte complexes retrieved during oocyte retrieval was comparable (P = 0.054), and a significant difference in oocyte maturity rate with median number of vitrified oocytes was found (P = 0.03, P < 0.001, respectively). After adjusting for confounders a multivariate analysis found no association between the type of contraceptive and proportion of metaphase II oocytes available for cryopreservation.
CONCLUSIONS: Among the various forms of contraception, none was shown to have an adverse association with oocyte yield or maturation rate in patients undergoing POC.
摘要：
目的：各种形式的激素和非激素避孕药是否与卵巢刺激结果有任何关联，如卵母细胞产量和成熟，
方法：这项回顾性队列研究纳入了2011年至2023年接受POC周期的所有患者。记录POC周期前避孕类型的使用情况。该研究评估了阴道卵母细胞取出后获得的卵丘-卵母细胞复合物的中位数以及所有队列中经历玻璃化的中期II卵母细胞的比例。
结果：总共4059个卵母细胞冷冻周期被纳入分析。在接受卵巢刺激的患者中认识到八种类型的避孕方法：宫内节育器（IUD），铜（n=84）；宫内节育器，左炔诺孕酮低剂量（<52mg）（n=37）；宫内节育器，左炔诺孕酮（n=192）；依托孕酮皮下植入（n=14）；可注射的醋酸甲羟孕酮（n=11）；依托孕酮阴道环（n=142）；联合口服避孕药（n=2349）；和norelgestromin透皮贴剂（n=10）。对照组包括不使用避孕药或使用屏障或日历方法的患者（n=1220）。在所有队列中，取卵过程中获取的卵丘-卵母细胞复合物的中位数具有可比性（P=0.054），并且发现卵母细胞成熟率与玻璃化卵母细胞的中位数之间存在显着差异（分别为P=0.03，P<0.001）。在校正混杂因素后，多变量分析发现避孕药的类型与可用于冷冻保存的中期II卵母细胞的比例之间没有关联。
结论：在各种避孕方式中，在接受POC的患者中，没有发现与卵母细胞产量或成熟率存在不良关联。
方法：这项回顾性队列研究纳入了2011年至2023年接受POC周期的所有患者。记录POC周期前避孕类型的使用情况。该研究评估了阴道卵母细胞取出后获得的卵丘-卵母细胞复合物的中位数以及所有队列中经历玻璃化的中期II卵母细胞的比例。
结果：总共4059个卵母细胞冷冻周期被纳入分析。在接受卵巢刺激的患者中认识到八种类型的避孕方法：宫内节育器（IUD），铜（n=84）；宫内节育器，左炔诺孕酮低剂量（<52mg）（n=37）；宫内节育器，左炔诺孕酮（n=192）；依托孕酮皮下植入（n=14）；可注射的醋酸甲羟孕酮（n=11）；依托孕酮阴道环（n=142）；联合口服避孕药（n=2349）；和norelgestromin透皮贴剂（n=10）。对照组包括不使用避孕药或使用屏障或日历方法的患者（n=1220）。在所有队列中，取卵过程中获取的卵丘-卵母细胞复合物的中位数具有可比性（P=0.054），并且发现卵母细胞成熟率与玻璃化卵母细胞的中位数之间存在显着差异（分别为P=0.03，P<0.001）。在校正混杂因素后，多变量分析发现避孕药的类型与可用于冷冻保存的中期II卵母细胞的比例之间没有关联。
结论：在各种避孕方式中，在接受POC的患者中，没有发现与卵母细胞产量或成熟率存在不良关联。
