{Reference Type}: Journal Article
{Title}: Effect of various contraceptives on oocyte yield and maturation in patients undergoing planned oocyte cryopreservation.
{Author}: Hernandez-Nieto C;Siddiqui S;Mejia-Fernandez L;Alkon-Meadows T;Lee J;Slifkin R;Mukherjee T;Copperman AB;
{Journal}: Reprod Biomed Online
{Volume}: 49
{Issue}: 3
{Year}: 2024 May 7
{Factor}: 4.567
{DOI}: 10.1016/j.rbmo.2024.104105
{Abstract}: <B>OBJECTIVE: </B>Do the various forms of hormonal and non-hormonal contraceptives have any association with ovarian stimulation outcomes, such as oocyte yield and maturation, in patients undergoing planned oocyte cryopreservation (POC)?<BR><B>METHODS: </B>This retrospective cohort study included all patients who underwent POC cycles between 2011 and 2023. The use of types of contraception before a POC cycle was recorded. The study evaluated the median number of cumulus-oocyte complexes obtained after vaginal oocyte retrieval and the proportion of metaphase II oocytes that underwent vitrification among all the cohorts.<BR><B>RESULTS: </B>A total of 4059 oocyte freezing cycles were included in the analysis. Eight types of contraceptive method were recognized in patients undergoing ovarian stimulation: intrauterine device (IUD), copper (n = 84); IUD, levonorgestrel low dose (<52 mg) (n = 37); IUD, levonorgestrel (n = 192); subdermal etonogestrel implant (n = 14); injectable medroxyprogesterone acetate (n = 11); etonogestrel vaginal ring (n = 142); combined oral contraceptive pills (n = 2349); and norelgestromin transdermal patch (n = 10). The control group included patients not using contraceptives or using barrier or calendar methods (n = 1220). Among all the cohorts the median number of cumulus-oocyte complexes retrieved during oocyte retrieval was comparable (P = 0.054), and a significant difference in oocyte maturity rate with median number of vitrified oocytes was found (P = 0.03, P < 0.001, respectively). After adjusting for confounders a multivariate analysis found no association between the type of contraceptive and proportion of metaphase II oocytes available for cryopreservation.<BR><B>CONCLUSIONS: </B>Among the various forms of contraception, none was shown to have an adverse association with oocyte yield or maturation rate in patients undergoing POC.