PDF(Pubmed)
Abstract：
BACKGROUND: The most deadly type of spontaneous intracerebral hemorrhage is spontaneous cerebellar hemorrhage (SCH). The purpose of this meta-analysis was to investigate risk factors for prognosis in SCH patients to provide a basis for taking preventive and therapeutic measures.
METHODS: Seven electronic databases were searched from inception to May 2023 for randomized controlled trial, cohort study, case control study and cross-sectional study on prognosis of spontaneous cerebellar hemorrhage. The quality of the selected studies were assessed by the American Agency for Healthcare Research and Quality (AHRQ). To assess the impact of the included risk factors on the prognosis of spontaneous cerebellar hemorrhage, combined odds ratios (ORs) with matching 95% confidence intervals (CIs) were combined.
RESULTS: Eight studies were included, including 539 participants. And a total of 31 potentially associated risk factors were identified. Ultimately, 6 risk factors were included in the meta-analysis after assessing. The factors supported by moderate evidence include the hydrocephalus (OR = 4.3, 95% CI: 2.33 to 7.91) and drug-induced coagulopathy (OR = 2.74, 95% CI: 1.23 to 6.09). The factors supported by limited evidence include the intraventricular bleeding(OR = 1.86, 95% CI: 1.13 to 3.07) and hematoma size>3 cm(OR = 3.18, 95% CI: 1.87 to 5.39). Meta-analysis revealed no association between hypertension, diabetes mellitus and SCH prognosis.
CONCLUSIONS: The current meta-analysis revealed obvious risk factors for prognosis in spontaneous cerebellar hemorrhage patients, including hydrocephalus, drug-induced coagulopathy, intraventricular bleeding and hematoma size>3 cm.
METHODS: Seven electronic databases were searched from inception to May 2023 for randomized controlled trial, cohort study, case control study and cross-sectional study on prognosis of spontaneous cerebellar hemorrhage. The quality of the selected studies were assessed by the American Agency for Healthcare Research and Quality (AHRQ). To assess the impact of the included risk factors on the prognosis of spontaneous cerebellar hemorrhage, combined odds ratios (ORs) with matching 95% confidence intervals (CIs) were combined.
RESULTS: Eight studies were included, including 539 participants. And a total of 31 potentially associated risk factors were identified. Ultimately, 6 risk factors were included in the meta-analysis after assessing. The factors supported by moderate evidence include the hydrocephalus (OR = 4.3, 95% CI: 2.33 to 7.91) and drug-induced coagulopathy (OR = 2.74, 95% CI: 1.23 to 6.09). The factors supported by limited evidence include the intraventricular bleeding(OR = 1.86, 95% CI: 1.13 to 3.07) and hematoma size>3 cm(OR = 3.18, 95% CI: 1.87 to 5.39). Meta-analysis revealed no association between hypertension, diabetes mellitus and SCH prognosis.
CONCLUSIONS: The current meta-analysis revealed obvious risk factors for prognosis in spontaneous cerebellar hemorrhage patients, including hydrocephalus, drug-induced coagulopathy, intraventricular bleeding and hematoma size>3 cm.
摘要：
背景：自发性脑出血最致命的类型是自发性小脑出血（SCH）。本Meta分析旨在探讨SCH患者预后的危险因素，为采取防治措施提供依据。
方法：从开始到2023年5月搜索了七个电子数据库进行随机对照试验，队列研究,自发性小脑出血预后的病例对照研究和横断面研究.所选研究的质量由美国医疗保健研究和质量机构(AHRQ)评估。评估纳入的危险因素对自发性小脑出血预后的影响。将具有匹配的95%置信区间(CIs)的组合比值比(ORs)合并.
结果：纳入了8项研究，包括539人。总共确定了31个潜在的相关危险因素。最终,评估后，将6个危险因素纳入荟萃分析。中度证据支持的因素包括脑积水（OR=4.3，95％CI：2.33至7.91）和药物性凝血病（OR=2.74，95％CI：1.23至6.09）。有限证据支持的因素包括脑室内出血（OR=1.86，95％CI：1.13至3.07）和血肿大小>3cm（OR=3.18，95％CI：1.87至5.39）。Meta分析显示高血压，糖尿病和SCH预后。
结论：目前的荟萃分析揭示了自发性小脑出血患者预后的明显危险因素。包括脑积水,药物性凝血病，脑室出血和血肿大小>3厘米。
方法：从开始到2023年5月搜索了七个电子数据库进行随机对照试验，队列研究,自发性小脑出血预后的病例对照研究和横断面研究.所选研究的质量由美国医疗保健研究和质量机构(AHRQ)评估。评估纳入的危险因素对自发性小脑出血预后的影响。将具有匹配的95%置信区间(CIs)的组合比值比(ORs)合并.
结果：纳入了8项研究，包括539人。总共确定了31个潜在的相关危险因素。最终,评估后，将6个危险因素纳入荟萃分析。中度证据支持的因素包括脑积水（OR=4.3，95％CI：2.33至7.91）和药物性凝血病（OR=2.74，95％CI：1.23至6.09）。有限证据支持的因素包括脑室内出血（OR=1.86，95％CI：1.13至3.07）和血肿大小>3cm（OR=3.18，95％CI：1.87至5.39）。Meta分析显示高血压，糖尿病和SCH预后。
结论：目前的荟萃分析揭示了自发性小脑出血患者预后的明显危险因素。包括脑积水,药物性凝血病，脑室出血和血肿大小>3厘米。
