Abstract：
For over five decades, many experimental and clinical studies have shown predominantly positive but controversial results on the efficacy of hyperbaric oxygen (HBO2) therapy in burns. The study aimed to define a common denominator or constellations, respectively, linked to the effects of HBO2 in burns with a special focus on dosage parameters. Based on original work since 1965, species, number of individuals, type of study, percentage of total body surface area (TBSA), region, depth of burn, causative agent, interval between burn and first HBO2 session, pressure, duration of individual session, number of HBO2 sessions per day, cumulative number of HBO2 sessions and type of chamber were assessed. Out of 47 publications included, 32 were animal trials, four were trials in human volunteers, and 11 were clinical studies. They contained 94 experiments whose features were processed for statistical evaluation. 64 (67.4%) showed a positive outcome, 16 (17.9%) an ambiguous one, and 14 (14.7%) a negative outcome. The only factor independently influencing the results was pressure with ATA (atmospheres absolute) lower than 3 ATA being significantly associated with better outcomes (p=0.0005). There is a dire need for well-designed clinical studies in burn centers equipped with hyperbaric facilities to establish dedicated treatment protocols.
摘要：
五十多年来,许多实验和临床研究表明,高压氧(HBO2)治疗烧伤的疗效主要为阳性,但有争议.这项研究旨在定义公分母或星座，分别,与HBO2在烧伤中的作用有关，特别关注剂量参数。基于1965年以来的原创作品，物种，个人数量,研究类型,总表面积（TBSA）的百分比，区域,烧伤深度,病原体，燃烧和第一次HBO2会话之间的间隔，压力,单独会话的持续时间，每天的HBO2会话数量，我们评估了HBO2治疗的累积次数和治疗室类型.包括47种出版物，32是动物试验，四次是在人类志愿者中进行的试验，和11个是临床研究。它们包含94个实验，其特征经过处理以进行统计评估。64（67.4%）显示积极的结果，16（17.9％）模棱两可，和14（14.7%）负面结果。影响结果的唯一独立因素是ATA（绝对大气压）低于3ATA的压力与更好的结果显着相关（p=0.0005）。迫切需要在配备高压设施的烧伤中心进行精心设计的临床研究，以建立专门的治疗方案。
