Abstract：
UNASSIGNED: Neurological disorders are common in preterm (PT) born individuals. Diffusion tensor imaging (DTI) studies using tract-based spatial statistics (TBSS) effectively detect microstructural white matter (WM) abnormalities in the brain. We conducted this systematic review to integrate the findings of TBSS studies to determine the most consistent WM alterations in PT born individuals.
UNASSIGNED: PubMed, Embase, Web of Science and Science Direct were searched. DTI studies using TBSS in PT born individuals were screened up to October 2022. The systematic review included studies reporting alterations in FA values for the entire brain in a stereotactic space, with three coordinates (x, y, z), according to the seed-based d mapping method.
UNASSIGNED: The search strategy identified seventeen studies that fulfilled our inclusion criteria, with a total of 911 PT-born individuals and 563 matched controls were analysed. Of the seventeen studies, eight were dedicated to 650 adults, five to 411 children and four to 413 infants. Ten studies recruited 812 individuals born very prematurely (GA <29 weeks), six studies recruited 386 moderately premature individuals (GA = 29-32 weeks) and one study recruited 276 individuals born late prematurely (GA >32 weeks). This meta-analysis of six studies including 388 individuals highlighted four brain regions in which fractional anisotropy (FA) was lower in PT group than in people born at term. The quantitative meta-analysis found that the most robust WM alterations were located in the corpus callosum (CC), the bilateral thalamus and the left superior longitudinal fasciculus (SLF) II. Significant changes in FA reflect WM abnormalities in PT born individuals from infant to young adulthood.
UNASSIGNED: Significant changes in FA reflect WM abnormalities in individuals born PT from infancy to young adulthood. The abnormal development of the CC, bilateral thalamus and left SLF may play a vital role in the neurodevelopment of PT individuals.
Neurological disorders are prevalent in preterm (PT) born individuals. The use of tract-based spatial statistics (TBSS) in diffusion tensor imaging (DTI) studies has proven effective in detecting microstructural abnormalities of the white matter (WM) of the brain. In order to determine the most consistent alterations in WM among those born prematurely, we have screened DTI studies using TBSS in this PT born population up until October 2022. The meta-analysis identified four brain regions where fractional anisotropy (FA) was lower in the PT group than in those born at term. The quantitative meta-analysis identified the corpus callosum, the bilateral thalamus and the left superior longitudinal fasciculus II. As the most robust WM alterations. Various studies have demonstrated the links between PT birth, intelligence quotient, gestational age and subject age.
UNASSIGNED: PubMed, Embase, Web of Science and Science Direct were searched. DTI studies using TBSS in PT born individuals were screened up to October 2022. The systematic review included studies reporting alterations in FA values for the entire brain in a stereotactic space, with three coordinates (x, y, z), according to the seed-based d mapping method.
UNASSIGNED: The search strategy identified seventeen studies that fulfilled our inclusion criteria, with a total of 911 PT-born individuals and 563 matched controls were analysed. Of the seventeen studies, eight were dedicated to 650 adults, five to 411 children and four to 413 infants. Ten studies recruited 812 individuals born very prematurely (GA <29 weeks), six studies recruited 386 moderately premature individuals (GA = 29-32 weeks) and one study recruited 276 individuals born late prematurely (GA >32 weeks). This meta-analysis of six studies including 388 individuals highlighted four brain regions in which fractional anisotropy (FA) was lower in PT group than in people born at term. The quantitative meta-analysis found that the most robust WM alterations were located in the corpus callosum (CC), the bilateral thalamus and the left superior longitudinal fasciculus (SLF) II. Significant changes in FA reflect WM abnormalities in PT born individuals from infant to young adulthood.
UNASSIGNED: Significant changes in FA reflect WM abnormalities in individuals born PT from infancy to young adulthood. The abnormal development of the CC, bilateral thalamus and left SLF may play a vital role in the neurodevelopment of PT individuals.
Neurological disorders are prevalent in preterm (PT) born individuals. The use of tract-based spatial statistics (TBSS) in diffusion tensor imaging (DTI) studies has proven effective in detecting microstructural abnormalities of the white matter (WM) of the brain. In order to determine the most consistent alterations in WM among those born prematurely, we have screened DTI studies using TBSS in this PT born population up until October 2022. The meta-analysis identified four brain regions where fractional anisotropy (FA) was lower in the PT group than in those born at term. The quantitative meta-analysis identified the corpus callosum, the bilateral thalamus and the left superior longitudinal fasciculus II. As the most robust WM alterations. Various studies have demonstrated the links between PT birth, intelligence quotient, gestational age and subject age.
摘要：
■神经系统疾病在早产（PT）出生的个体中很常见。使用基于束的空间统计（TBSS）的扩散张量成像（DTI）研究可有效检测大脑中的微结构白质（WM）异常。我们进行了这项系统评价，以整合TBSS研究的结果，以确定PT出生个体中最一致的WM改变。
■PubMed,Embase,搜索了WebofScience和ScienceDirect。截至2022年10月，对PT出生个体使用TBSS的DTI研究进行了筛选。系统评价包括报告立体定向空间中整个大脑FA值变化的研究，三个坐标(x,y,z),根据基于种子的d映射方法。
■搜索策略确定了17项符合我们纳入标准的研究，共分析了911名PT出生个体和563名匹配对照.在17项研究中，八个是献给650名成年人的，5至411名儿童和4至413名婴儿。10项研究招募了812名早产的人（GA<29周），6项研究招募了386名中度早产个体(GA=29-32周),1项研究招募了276名早产晚期个体(GA>32周).这项对包括388名个体的六项研究的荟萃分析强调了四个大脑区域，其中PT组的各向异性分数（FA）低于足月出生的人。定量荟萃分析发现，最稳健的WM改变位于call体（CC）中，双侧丘脑和左上纵束（SLF）II。FA的显着变化反映了从婴儿到成年的PT出生个体的WM异常。
■FA的显著变化反映了从婴儿期到年轻成年期出生的PT个体的WM异常。CC的异常发展，双侧丘脑和左侧SLF可能在PT个体的神经发育中起重要作用。
神经系统疾病在早产（PT）出生的个体中很普遍。在扩散张量成像（DTI）研究中使用基于束的空间统计（TBSS）已被证明可有效检测大脑白质（WM）的微结构异常。为了确定早产人群中WM最一致的改变，我们已经在该PT出生人群中使用TBSS筛选了DTI研究，直至2022年10月。荟萃分析确定了PT组中各向异性分数（FA）低于足月出生的四个大脑区域。定量荟萃分析确定了call体，双侧丘脑和左上纵束II。作为最健壮的WM改变。各种研究已经证明了PT出生之间的联系，智商,胎龄和受试者年龄。
■PubMed,Embase,搜索了WebofScience和ScienceDirect。截至2022年10月，对PT出生个体使用TBSS的DTI研究进行了筛选。系统评价包括报告立体定向空间中整个大脑FA值变化的研究，三个坐标(x,y,z),根据基于种子的d映射方法。
■搜索策略确定了17项符合我们纳入标准的研究，共分析了911名PT出生个体和563名匹配对照.在17项研究中，八个是献给650名成年人的，5至411名儿童和4至413名婴儿。10项研究招募了812名早产的人（GA<29周），6项研究招募了386名中度早产个体(GA=29-32周),1项研究招募了276名早产晚期个体(GA>32周).这项对包括388名个体的六项研究的荟萃分析强调了四个大脑区域，其中PT组的各向异性分数（FA）低于足月出生的人。定量荟萃分析发现，最稳健的WM改变位于call体（CC）中，双侧丘脑和左上纵束（SLF）II。FA的显着变化反映了从婴儿到成年的PT出生个体的WM异常。
■FA的显著变化反映了从婴儿期到年轻成年期出生的PT个体的WM异常。CC的异常发展，双侧丘脑和左侧SLF可能在PT个体的神经发育中起重要作用。
神经系统疾病在早产（PT）出生的个体中很普遍。在扩散张量成像（DTI）研究中使用基于束的空间统计（TBSS）已被证明可有效检测大脑白质（WM）的微结构异常。为了确定早产人群中WM最一致的改变，我们已经在该PT出生人群中使用TBSS筛选了DTI研究，直至2022年10月。荟萃分析确定了PT组中各向异性分数（FA）低于足月出生的四个大脑区域。定量荟萃分析确定了call体，双侧丘脑和左上纵束II。作为最健壮的WM改变。各种研究已经证明了PT出生之间的联系，智商,胎龄和受试者年龄。
