Abstract：
Alterations in vascular extracellular matrix (ECM) components, interactions, and mechanical properties influence both the formation and stability of atherosclerotic plaques. This review discusses the contribution of the ECM microenvironment in vascular homeostasis and remodeling in atherosclerosis, highlighting Cartilage oligomeric matrix protein (COMP) and its degrading enzyme ADAMTS7 as examples, and proposes potential avenues for future research aimed at identifying novel therapeutic targets for atherosclerosis based on the ECM microenvironment.
摘要：
血管细胞外基质（ECM）成分的变化，互动,机械特性影响动脉粥样硬化斑块的形成和稳定性。这篇综述讨论了ECM微环境在动脉粥样硬化血管稳态和重塑中的作用。以软骨寡聚基质蛋白（COMP）及其降解酶ADAMTS7为例，并提出了未来研究的潜在途径，旨在基于ECM微环境确定动脉粥样硬化的新治疗靶标。
