PDF(Pubmed)
Abstract：
UNASSIGNED: The presence of low voltage zones (LVZs) in the left atrium (LA) is associated with the recurrence of atrial fibrillation (AF) after pulmonary vein isolation. Numerous studies have posited a link between gastroesophageal reflux disease (GERD) and AF, attributing this relationship to the anatomical proximity of the esophagus to the posteroinferior wall of the LA.
UNASSIGNED: The objective of this study was to investigate whether GERD can predict the presence of LVZs in the posteroinferior wall of the LA.
UNASSIGNED: Five hundred fifty-one patients with persistent AF, scheduled for their first AF ablation procedure, were prospectively enrolled. Voltage maps were collected using a multipolar catheter, and LVZs were defined as areas measuring ≥3 cm2 with a peak-to-peak bipolar voltage of <0.5 mV. Information on GERD symptoms was collected from the participants through a self-administered questionnaire.
UNASSIGNED: Long-standing persistent AF was present in 22.3% of the total cohort. GERD was present in 29% of patients and LVZs in the posteroinferior wall in 12.7%. In the multivariable analysis, patients with GERD were found to have more than twice the odds (odds ratio 2.26; 95% confidence interval 1.24-4.13; P = .008) of exhibiting LVZs in the posteroinferior wall of the LA than patients without GERD. GERD was not associated with LVZs in any other region of the LA.
UNASSIGNED: GERD was found to be independently associated with LVZs in the posteroinferior LA. This association may be attributable to inflammation and may partly explain the link between GERD and AF.
UNASSIGNED: The objective of this study was to investigate whether GERD can predict the presence of LVZs in the posteroinferior wall of the LA.
UNASSIGNED: Five hundred fifty-one patients with persistent AF, scheduled for their first AF ablation procedure, were prospectively enrolled. Voltage maps were collected using a multipolar catheter, and LVZs were defined as areas measuring ≥3 cm2 with a peak-to-peak bipolar voltage of <0.5 mV. Information on GERD symptoms was collected from the participants through a self-administered questionnaire.
UNASSIGNED: Long-standing persistent AF was present in 22.3% of the total cohort. GERD was present in 29% of patients and LVZs in the posteroinferior wall in 12.7%. In the multivariable analysis, patients with GERD were found to have more than twice the odds (odds ratio 2.26; 95% confidence interval 1.24-4.13; P = .008) of exhibiting LVZs in the posteroinferior wall of the LA than patients without GERD. GERD was not associated with LVZs in any other region of the LA.
UNASSIGNED: GERD was found to be independently associated with LVZs in the posteroinferior LA. This association may be attributable to inflammation and may partly explain the link between GERD and AF.
摘要：
■左心房（LA）中低压区（LVZs）的存在与肺静脉隔离后心房颤动（AF）的复发有关。许多研究认为胃食管反流病（GERD）与房颤之间存在联系，将这种关系归因于食道与LA后下壁的解剖学接近度。
■这项研究的目的是调查GERD是否可以预测LA后下壁中LVZ的存在。
■5151名持续性房颤患者，计划进行他们的第一次房颤消融手术，被前瞻性登记。使用多极导管收集电压图，和LVZ定义为测量≥3cm2的面积,峰-峰双极电压<0.5mV。关于GERD症状的信息是通过自我管理的问卷从参与者那里收集的。
■长期持续性房颤占总队列的22.3%。29％的患者存在GERD，后下壁的LVZ占12.7％。在多变量分析中，与无GERD患者相比,GERD患者在LA后下壁出现LVZ的几率(比值比2.26;95%置信区间1.24~4.13;P=.008)超过2倍.GERD与LA其他区域的LVZs无关。
■在后下LA中发现GERD与LVZ独立相关。这种关联可能归因于炎症，并可能部分解释GERD和AF之间的联系。
■这项研究的目的是调查GERD是否可以预测LA后下壁中LVZ的存在。
■5151名持续性房颤患者，计划进行他们的第一次房颤消融手术，被前瞻性登记。使用多极导管收集电压图，和LVZ定义为测量≥3cm2的面积,峰-峰双极电压<0.5mV。关于GERD症状的信息是通过自我管理的问卷从参与者那里收集的。
■长期持续性房颤占总队列的22.3%。29％的患者存在GERD，后下壁的LVZ占12.7％。在多变量分析中，与无GERD患者相比,GERD患者在LA后下壁出现LVZ的几率(比值比2.26;95%置信区间1.24~4.13;P=.008)超过2倍.GERD与LA其他区域的LVZs无关。
■在后下LA中发现GERD与LVZ独立相关。这种关联可能归因于炎症，并可能部分解释GERD和AF之间的联系。
