UNASSIGNED: The objective of this study was to investigate whether GERD can predict the presence of LVZs in the posteroinferior wall of the LA.
UNASSIGNED: Five hundred fifty-one patients with persistent AF, scheduled for their first AF ablation procedure, were prospectively enrolled. Voltage maps were collected using a multipolar catheter, and LVZs were defined as areas measuring ≥3 cm2 with a peak-to-peak bipolar voltage of <0.5 mV. Information on GERD symptoms was collected from the participants through a self-administered questionnaire.
UNASSIGNED: Long-standing persistent AF was present in 22.3% of the total cohort. GERD was present in 29% of patients and LVZs in the posteroinferior wall in 12.7%. In the multivariable analysis, patients with GERD were found to have more than twice the odds (odds ratio 2.26; 95% confidence interval 1.24-4.13; P = .008) of exhibiting LVZs in the posteroinferior wall of the LA than patients without GERD. GERD was not associated with LVZs in any other region of the LA.
UNASSIGNED: GERD was found to be independently associated with LVZs in the posteroinferior LA. This association may be attributable to inflammation and may partly explain the link between GERD and AF.
■这项研究的目的是调查GERD是否可以预测LA后下壁中LVZ的存在。
■5151名持续性房颤患者,计划进行他们的第一次房颤消融手术,被前瞻性登记。使用多极导管收集电压图,和LVZ定义为测量≥3cm2的面积,峰-峰双极电压<0.5mV。关于GERD症状的信息是通过自我管理的问卷从参与者那里收集的。
■长期持续性房颤占总队列的22.3%。29%的患者存在GERD,后下壁的LVZ占12.7%。在多变量分析中,与无GERD患者相比,GERD患者在LA后下壁出现LVZ的几率(比值比2.26;95%置信区间1.24~4.13;P=.008)超过2倍.GERD与LA其他区域的LVZs无关。
■在后下LA中发现GERD与LVZ独立相关。这种关联可能归因于炎症,并可能部分解释GERD和AF之间的联系。