PDF(Pubmed)
Abstract：
Alopecia is considered a widespread yet troubling health issue, with limited treatment options. As membranous structures derived from cells carrying proteins, nucleic acids and lipids, exosomes functionally medicate intercellular communication and alter the responses of recipient cells, resulting in disease restraint or promotion. Exosomes have broad prospects in diagnosis and treatment of diseases. Studies using animal models and at the cellular level have clearly shown that exosomes from several types of cells, including dermal papilla cells and mesenchymal stem cells, have a notable capacity to promote hair growth, suggesting that exosomes may provide a new option to treat alopecia. Here, we present a thorough review of the most recent progress in the application of exosomes to hair growth.
摘要：
脱发被认为是一个广泛但令人不安的健康问题，有限的治疗选择。作为来自携带蛋白质的细胞的膜结构，核酸和脂质，外泌体功能性药物细胞间通讯并改变受体细胞的反应，导致疾病的克制或促进。外泌体在疾病的诊断和治疗中具有广阔的前景。使用动物模型和细胞水平的研究清楚地表明，来自几种类型细胞的外泌体，包括毛乳头细胞和间充质干细胞，具有显著的促进头发生长的能力，这表明外泌体可能为治疗脱发提供新的选择。这里,我们对外泌体应用于毛发生长的最新进展进行了全面回顾.
