PDF(Pubmed)
Abstract：
Roles of genes in heat acclimation (HA, repeated exercise-heat exposures) had not been explored. ACE I/D and ACTN3 R577X genetic polymorphisms are closely associated with outstanding exercise performances. This study investigated whether the two polymorphisms influenced the response to HA. Fifty young Han nationality male subjects were selected and conducted HA for 2 weeks. Exercise indicators (5-km run, push-up and 100-m run) were tested and rest aural thermometry (RTau) was measured before and after HA. ACE gene was grouped by I homozygote and D carrier, and ACTN3 gene was grouped by R homozygote and X carrier. Results showed that there were no differences between groups in age, body mass index, exercise indicators and RTau before HA. After HA, RTau of ACE I homozygote was lower than that of D carrier [F (1, 48) = 9.12, p = 0.004, η = 0.40]. Compared with RTau before HA, that of I homozygote decreased after HA (Δ = -0.26 °C, 95 % CI -0.34-0.18, p < 0.001), while that of D carrier did not change. There was a ACE gene × HA interaction in RTau [F (1, 48) = 14.26, p < 0.001, η = 0.48]. No effect of ACTN3 gene on RTau was observed. For exercise indicators, there were no differences between groups after HA, and no gene × HA interactions were observed. There may be a strong interaction of ACE gene and HA in the change of rest core temperature. I homozygote may have an advantage on improving heat tolerance.
摘要：
基因在热适应中的作用(HA，反复运动-热暴露）尚未探索。ACEI/D和ACTN3R577X基因多态性与出色的运动表现密切相关。这项研究调查了两种多态性是否影响对HA的反应。选择50名年轻汉族男性受试者，进行2周的HA治疗。运动指标（5公里跑步，俯卧撑和100-m运行）进行了测试，并在HA之前和之后测量了休息听觉测温（RTau）。ACE基因按I纯合子和D携带者分组，ACTN3基因按R纯合子和X携带者分组。结果显示，两组之间的年龄没有差异，身体质量指数,运动指标和房委会前的RTau。HA之后,ACEI纯合子的RTau低于D携带者[F(1，48)=9.12，p=0.004，η=0.40]。与房委会之前的RTau相比，HA后I纯合子的含量降低(Δ=-0.26℃，95%CI-0.34-0.18，p<0.001)，而D承运人的情况没有改变。RTau中存在ACE基因×HA相互作用[F(1,48)=14.26,p<0.001,η=0.48]。未观察到ACTN3基因对RTau的影响。对于运动指标，HA后组间没有差异，未观察到基因×HA相互作用。ACE基因与HA在休息核心温度的变更中可能存在较强的互相感化。纯合子可能在提高耐热性方面具有优势。
