PDF(Pubmed)
Abstract：
UNASSIGNED: Phenylephrine (PE) is one of the vasopressor used to treat hypotension during anaesthesia. The primary aim of this study was to compare the effect of prophylactic infusion and rescue bolus of PE on the haemodynamic changes during spinal anaesthesia (SA) for Caesarean section (CS) in obese parturients.
UNASSIGNED: A total of 74 obese parturients scheduled for elective CS under SA were randomised into two groups; Group A (n = 37) received prophylactic PE infusion starting at 50 μg min-1 and adjusted according to the given algorithm and Group B (n = 37) received 100 μg PE bolus to treat hypotension. The measured parameters were systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), the total requirement of PE and neonatal Apgar score.
UNASSIGNED: Six patients were excluded from the analysis due to missing data and only 68 were analysed. Group A showed significantly higher SBP, DBP and MAP than Group B (P < 0.05). The requirement of PE was higher in Group A than Group B [817.7 (265.7) μg versus 360.6 (156.0) μg; P = < 0.05]. Both groups had no difference in terms of the neonatal Apgar score.
UNASSIGNED: Prophylactic PE infusion provided better haemodynamic control than therapeutic boluses in obese parturients undergoing CS under SA.
UNASSIGNED: A total of 74 obese parturients scheduled for elective CS under SA were randomised into two groups; Group A (n = 37) received prophylactic PE infusion starting at 50 μg min-1 and adjusted according to the given algorithm and Group B (n = 37) received 100 μg PE bolus to treat hypotension. The measured parameters were systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), the total requirement of PE and neonatal Apgar score.
UNASSIGNED: Six patients were excluded from the analysis due to missing data and only 68 were analysed. Group A showed significantly higher SBP, DBP and MAP than Group B (P < 0.05). The requirement of PE was higher in Group A than Group B [817.7 (265.7) μg versus 360.6 (156.0) μg; P = < 0.05]. Both groups had no difference in terms of the neonatal Apgar score.
UNASSIGNED: Prophylactic PE infusion provided better haemodynamic control than therapeutic boluses in obese parturients undergoing CS under SA.
摘要：
■去氧肾上腺素（PE）是一种用于治疗麻醉期间低血压的血管加压药。这项研究的主要目的是比较PE的预防性输注和抢救推注对肥胖产妇剖腹产（CS）的脊髓麻醉（SA）期间血流动力学变化的影响。
■将在SA下进行选择性CS的74例肥胖产妇随机分为两组；A组（n=37）从50μgmin-1开始接受预防性PE输注，并根据给定的算法进行调整，B组（n=37）接受100μgPE推注以治疗低血压。测量参数为收缩压（SBP），舒张压（DBP），平均动脉压(MAP),PE和新生儿Apgar评分的总要求。
■由于数据缺失，6名患者被排除在分析之外，只有68名患者被分析。A组SBP明显增高,DBP和MAP优于B组(P<0.05)。A组PE的需求量高于B组[817.7（265.7）μg对360.6（156.0）μg；P=<0.05]。两组新生儿Apgar评分无差异。
■在SA下接受CS的肥胖产妇中，预防性PE输注比治疗性推注提供更好的血流动力学控制。
■将在SA下进行选择性CS的74例肥胖产妇随机分为两组；A组（n=37）从50μgmin-1开始接受预防性PE输注，并根据给定的算法进行调整，B组（n=37）接受100μgPE推注以治疗低血压。测量参数为收缩压（SBP），舒张压（DBP），平均动脉压(MAP),PE和新生儿Apgar评分的总要求。
■由于数据缺失，6名患者被排除在分析之外，只有68名患者被分析。A组SBP明显增高,DBP和MAP优于B组(P<0.05)。A组PE的需求量高于B组[817.7（265.7）μg对360.6（156.0）μg；P=<0.05]。两组新生儿Apgar评分无差异。
■在SA下接受CS的肥胖产妇中，预防性PE输注比治疗性推注提供更好的血流动力学控制。
