PDF(Pubmed)
Abstract：
UNASSIGNED: Vasopressors remain an important strategy for managing spinal anesthesia-induced hypotension in women with preeclampsia. The aim of this study was to investigate the ED90s and efficacy ratio of phenylephrine and norepinephrine in managing spinal anesthesia-induced hypotension in women with preeclampsia during cesarean delivery.
UNASSIGNED: 60 women with preeclampsia, who underwent cesarean delivery, were randomly assigned to receive either a continuous intravenous infusion of phenylephrine or norepinephrine following spinal anesthesia. The initial dosage of phenylephrine or norepinephrine for the first women was 0.5 or 0.05 μg/kg/min, respectively, and subsequent infusion dosages were adjusted based on their efficacy in preventing spinal anesthesia-induced hypotension (defined as a systolic blood pressure less than 80% of the baseline level). The incremental or decremental doses of phenylephrine or norepinephrine were set at 0.1 or 0.01 μg/kg/min. The primary outcomes were the ED90s and efficacy ratio of phenylephrine and norepinephrine infusions for preventing spinal anesthesia-induced hypotension prior to delivery.
UNASSIGNED: The results obtained from isotonic regression analysis revealed that the ED90 values of the phenylephrine and norepinephrine group for preventing spinal anesthesia-induced hypotension were 0.597 (95% CI: 0.582-0.628) and 0.054 (95% CI: 0.053-0.056) μg/kg/min, respectively, with an efficacy ratio of 11.1:1. The results of Probit regression analysis revealed that the ED90 values were determined to be 0.665 (95% CI: 0.576-1.226) and 0.055 (95% CI: 0.047-0.109) μg/kg/min, respectively, with an efficacy ratio of 12.1:1.
UNASSIGNED: The administration of 0.6 μg/kg/min phenylephrine and 0.05 μg/kg/min norepinephrine has been found to effectively manage a 90% incidence of spinal anesthesia-induced hypotension in women with preeclampsia.
UNASSIGNED: 60 women with preeclampsia, who underwent cesarean delivery, were randomly assigned to receive either a continuous intravenous infusion of phenylephrine or norepinephrine following spinal anesthesia. The initial dosage of phenylephrine or norepinephrine for the first women was 0.5 or 0.05 μg/kg/min, respectively, and subsequent infusion dosages were adjusted based on their efficacy in preventing spinal anesthesia-induced hypotension (defined as a systolic blood pressure less than 80% of the baseline level). The incremental or decremental doses of phenylephrine or norepinephrine were set at 0.1 or 0.01 μg/kg/min. The primary outcomes were the ED90s and efficacy ratio of phenylephrine and norepinephrine infusions for preventing spinal anesthesia-induced hypotension prior to delivery.
UNASSIGNED: The results obtained from isotonic regression analysis revealed that the ED90 values of the phenylephrine and norepinephrine group for preventing spinal anesthesia-induced hypotension were 0.597 (95% CI: 0.582-0.628) and 0.054 (95% CI: 0.053-0.056) μg/kg/min, respectively, with an efficacy ratio of 11.1:1. The results of Probit regression analysis revealed that the ED90 values were determined to be 0.665 (95% CI: 0.576-1.226) and 0.055 (95% CI: 0.047-0.109) μg/kg/min, respectively, with an efficacy ratio of 12.1:1.
UNASSIGNED: The administration of 0.6 μg/kg/min phenylephrine and 0.05 μg/kg/min norepinephrine has been found to effectively manage a 90% incidence of spinal anesthesia-induced hypotension in women with preeclampsia.
摘要：
■血管加压药仍然是治疗先兆子痫妇女脊髓麻醉诱导的低血压的重要策略。这项研究的目的是研究去氧肾上腺素和去甲肾上腺素在剖宫产术中控制先兆子痫妇女脊髓麻醉引起的低血压中的ED90和功效比。
■60名先兆子痫妇女，接受剖腹产的人，在脊髓麻醉后随机分配接受持续静脉输注去氧肾上腺素或去甲肾上腺素.最初女性的去氧肾上腺素或去甲肾上腺素的初始剂量为0.5或0.05μg/kg/min，分别,随后的输注剂量根据其预防脊髓麻醉诱导的低血压(定义为收缩压低于基线水平的80%)的功效进行调整.苯肾上腺素或去甲肾上腺素的增量或减量设定为0.1或0.01μg/kg/min。主要结果是ED90和去氧肾上腺素和去甲肾上腺素输注预防分娩前脊髓麻醉引起的低血压的疗效比。
■等渗回归分析结果显示,去氧肾上腺素和去甲肾上腺素组预防腰麻低血压的ED90值分别为0.597(95%CI:0.582-0.628)和0.054(95%CI:0.053-0.056)μg/kg/min,分别,功效比为11.1:1。Probit回归分析结果表明，ED90值确定为0.665（95％CI：0.576-1.226）和0.055（95％CI：0.047-0.109）μg/kg/min，分别,功效比为12.1:1。
■已发现给予0.6μg/kg/min去氧肾上腺素和0.05μg/kg/min去甲肾上腺素可有效控制先兆子痫妇女脊髓麻醉诱导的低血压的90%发生率。
■60名先兆子痫妇女，接受剖腹产的人，在脊髓麻醉后随机分配接受持续静脉输注去氧肾上腺素或去甲肾上腺素.最初女性的去氧肾上腺素或去甲肾上腺素的初始剂量为0.5或0.05μg/kg/min，分别,随后的输注剂量根据其预防脊髓麻醉诱导的低血压(定义为收缩压低于基线水平的80%)的功效进行调整.苯肾上腺素或去甲肾上腺素的增量或减量设定为0.1或0.01μg/kg/min。主要结果是ED90和去氧肾上腺素和去甲肾上腺素输注预防分娩前脊髓麻醉引起的低血压的疗效比。
■等渗回归分析结果显示,去氧肾上腺素和去甲肾上腺素组预防腰麻低血压的ED90值分别为0.597(95%CI:0.582-0.628)和0.054(95%CI:0.053-0.056)μg/kg/min,分别,功效比为11.1:1。Probit回归分析结果表明，ED90值确定为0.665（95％CI：0.576-1.226）和0.055（95％CI：0.047-0.109）μg/kg/min，分别,功效比为12.1:1。
■已发现给予0.6μg/kg/min去氧肾上腺素和0.05μg/kg/min去甲肾上腺素可有效控制先兆子痫妇女脊髓麻醉诱导的低血压的90%发生率。
