PDF(Pubmed)
Abstract：
BACKGROUND: Obesity in children and adolescents is a serious problem, and the efficacy of exercise therapy for these patients is controversial.
OBJECTIVE: To assess the efficacy of exercise training on overweight and obese children based on glucose metabolism indicators and inflammatory markers.
METHODS: The PubMed, Web of Science, and Embase databases were searched for randomized controlled trials related to exercise training and obese children until October 2023. The meta-analysis was conducted using RevMan 5.3 software to evaluate the efficacy of exercise therapy on glucose metabolism indicators and inflammatory markers in obese children.
RESULTS: In total, 1010 patients from 28 studies were included. Exercise therapy reduced the levels of fasting blood glucose (FBG) [standardized mean difference (SMD): -0.78; 95% confidence interval (CI): -1.24 to -0.32, P = 0.0008], fasting insulin (FINS) (SMD: -1.55; 95%CI: -2.12 to -0.98, P < 0.00001), homeostatic model assessment for insulin resistance (HOMA-IR) (SMD: -1.58; 95%CI: -2.20 to -0.97, P < 0.00001), interleukin-6 (IL-6) (SMD: -1.31; 95%CI: -2.07 to -0.55, P = 0.0007), C-reactive protein (CRP) (SMD: -0.64; 95%CI: -1.21 to -0.08, P = 0.03), and leptin (SMD: -3.43; 95%CI: -5.82 to -1.05, P = 0.005) in overweight and obese children. Exercise training increased adiponectin levels (SMD: 1.24; 95%CI: 0.30 to 2.18, P = 0.01) but did not improve tumor necrosis factor-alpha (TNF-α) levels (SMD: -0.80; 95%CI: -1.77 to 0.18, P = 0.11).
CONCLUSIONS: In summary, exercise therapy improves glucose metabolism by reducing levels of FBG, FINS, HOMA-IR, as well as improves inflammatory status by reducing levels of IL-6, CRP, leptin, and increasing levels of adiponectin in overweight and obese children. There was no statistically significant effect between exercise training and levels of TNF-α. Additional long-term trials should be conducted to explore this therapeutic perspective and confirm these results.
OBJECTIVE: To assess the efficacy of exercise training on overweight and obese children based on glucose metabolism indicators and inflammatory markers.
METHODS: The PubMed, Web of Science, and Embase databases were searched for randomized controlled trials related to exercise training and obese children until October 2023. The meta-analysis was conducted using RevMan 5.3 software to evaluate the efficacy of exercise therapy on glucose metabolism indicators and inflammatory markers in obese children.
RESULTS: In total, 1010 patients from 28 studies were included. Exercise therapy reduced the levels of fasting blood glucose (FBG) [standardized mean difference (SMD): -0.78; 95% confidence interval (CI): -1.24 to -0.32, P = 0.0008], fasting insulin (FINS) (SMD: -1.55; 95%CI: -2.12 to -0.98, P < 0.00001), homeostatic model assessment for insulin resistance (HOMA-IR) (SMD: -1.58; 95%CI: -2.20 to -0.97, P < 0.00001), interleukin-6 (IL-6) (SMD: -1.31; 95%CI: -2.07 to -0.55, P = 0.0007), C-reactive protein (CRP) (SMD: -0.64; 95%CI: -1.21 to -0.08, P = 0.03), and leptin (SMD: -3.43; 95%CI: -5.82 to -1.05, P = 0.005) in overweight and obese children. Exercise training increased adiponectin levels (SMD: 1.24; 95%CI: 0.30 to 2.18, P = 0.01) but did not improve tumor necrosis factor-alpha (TNF-α) levels (SMD: -0.80; 95%CI: -1.77 to 0.18, P = 0.11).
CONCLUSIONS: In summary, exercise therapy improves glucose metabolism by reducing levels of FBG, FINS, HOMA-IR, as well as improves inflammatory status by reducing levels of IL-6, CRP, leptin, and increasing levels of adiponectin in overweight and obese children. There was no statistically significant effect between exercise training and levels of TNF-α. Additional long-term trials should be conducted to explore this therapeutic perspective and confirm these results.
摘要：
背景：儿童和青少年肥胖是一个严重的问题，运动疗法对这些患者的疗效存在争议。
目的：根据糖代谢指标和炎症指标评估运动训练对超重和肥胖儿童的疗效。
方法：PubMed，WebofScience,在Embase数据库中搜索与运动训练和肥胖儿童相关的随机对照试验,直至2023年10月.采用RevMan5.3软件进行Meta分析,评价运动疗法对肥胖儿童糖代谢指标和炎症指标的影响。
结果：总计，共纳入28项研究的1010名患者。运动疗法降低了空腹血糖（FBG）水平[标准化平均差（SMD）：-0.78；95％置信区间（CI）：-1.24至-0.32，P=0.0008]，空腹胰岛素（FINS）（SMD：-1.55;95CI：-2.12至-0.98，P<0.00001），胰岛素抵抗的稳态模型评估（HOMA-IR）（SMD：-1.58;95CI：-2.20至-0.97，P<0.00001），白细胞介素-6（IL-6）（SMD：-1.31;95CI：-2.07至-0.55，P=0.0007），C反应蛋白（CRP）（SMD：-0.64;95CI：-1.21至-0.08，P=0.03），超重和肥胖儿童的瘦素（SMD：-3.43；95CI：-5.82至-1.05，P=0.005）。运动训练可增加脂联素水平(SMD:1.24;95CI:0.30~2.18,P=0.01),但不能改善肿瘤坏死因子-α(TNF-α)水平(SMD:-0.80;95CI:-1.77~0.18,P=0.11)。
结论：总之，运动疗法通过降低FBG水平改善葡萄糖代谢，FINS,HOMA-IR,以及通过降低IL-6，CRP水平改善炎症状态，瘦素,超重和肥胖儿童的脂联素水平升高。运动训练与TNF-α水平之间无统计学意义。应进行其他长期试验以探索这种治疗观点并确认这些结果。
目的：根据糖代谢指标和炎症指标评估运动训练对超重和肥胖儿童的疗效。
方法：PubMed，WebofScience,在Embase数据库中搜索与运动训练和肥胖儿童相关的随机对照试验,直至2023年10月.采用RevMan5.3软件进行Meta分析,评价运动疗法对肥胖儿童糖代谢指标和炎症指标的影响。
结果：总计，共纳入28项研究的1010名患者。运动疗法降低了空腹血糖（FBG）水平[标准化平均差（SMD）：-0.78；95％置信区间（CI）：-1.24至-0.32，P=0.0008]，空腹胰岛素（FINS）（SMD：-1.55;95CI：-2.12至-0.98，P<0.00001），胰岛素抵抗的稳态模型评估（HOMA-IR）（SMD：-1.58;95CI：-2.20至-0.97，P<0.00001），白细胞介素-6（IL-6）（SMD：-1.31;95CI：-2.07至-0.55，P=0.0007），C反应蛋白（CRP）（SMD：-0.64;95CI：-1.21至-0.08，P=0.03），超重和肥胖儿童的瘦素（SMD：-3.43；95CI：-5.82至-1.05，P=0.005）。运动训练可增加脂联素水平(SMD:1.24;95CI:0.30~2.18,P=0.01),但不能改善肿瘤坏死因子-α(TNF-α)水平(SMD:-0.80;95CI:-1.77~0.18,P=0.11)。
结论：总之，运动疗法通过降低FBG水平改善葡萄糖代谢，FINS,HOMA-IR,以及通过降低IL-6，CRP水平改善炎症状态，瘦素,超重和肥胖儿童的脂联素水平升高。运动训练与TNF-α水平之间无统计学意义。应进行其他长期试验以探索这种治疗观点并确认这些结果。
