OBJECTIVE: To assess the efficacy of exercise training on overweight and obese children based on glucose metabolism indicators and inflammatory markers.
METHODS: The PubMed, Web of Science, and Embase databases were searched for randomized controlled trials related to exercise training and obese children until October 2023. The meta-analysis was conducted using RevMan 5.3 software to evaluate the efficacy of exercise therapy on glucose metabolism indicators and inflammatory markers in obese children.
RESULTS: In total, 1010 patients from 28 studies were included. Exercise therapy reduced the levels of fasting blood glucose (FBG) [standardized mean difference (SMD): -0.78; 95% confidence interval (CI): -1.24 to -0.32, P = 0.0008], fasting insulin (FINS) (SMD: -1.55; 95%CI: -2.12 to -0.98, P < 0.00001), homeostatic model assessment for insulin resistance (HOMA-IR) (SMD: -1.58; 95%CI: -2.20 to -0.97, P < 0.00001), interleukin-6 (IL-6) (SMD: -1.31; 95%CI: -2.07 to -0.55, P = 0.0007), C-reactive protein (CRP) (SMD: -0.64; 95%CI: -1.21 to -0.08, P = 0.03), and leptin (SMD: -3.43; 95%CI: -5.82 to -1.05, P = 0.005) in overweight and obese children. Exercise training increased adiponectin levels (SMD: 1.24; 95%CI: 0.30 to 2.18, P = 0.01) but did not improve tumor necrosis factor-alpha (TNF-α) levels (SMD: -0.80; 95%CI: -1.77 to 0.18, P = 0.11).
CONCLUSIONS: In summary, exercise therapy improves glucose metabolism by reducing levels of FBG, FINS, HOMA-IR, as well as improves inflammatory status by reducing levels of IL-6, CRP, leptin, and increasing levels of adiponectin in overweight and obese children. There was no statistically significant effect between exercise training and levels of TNF-α. Additional long-term trials should be conducted to explore this therapeutic perspective and confirm these results.
目的:根据糖代谢指标和炎症指标评估运动训练对超重和肥胖儿童的疗效。
方法:PubMed,WebofScience,在Embase数据库中搜索与运动训练和肥胖儿童相关的随机对照试验,直至2023年10月.采用RevMan5.3软件进行Meta分析,评价运动疗法对肥胖儿童糖代谢指标和炎症指标的影响。
结果:总计,共纳入28项研究的1010名患者。运动疗法降低了空腹血糖(FBG)水平[标准化平均差(SMD):-0.78;95%置信区间(CI):-1.24至-0.32,P=0.0008],空腹胰岛素(FINS)(SMD:-1.55;95CI:-2.12至-0.98,P<0.00001),胰岛素抵抗的稳态模型评估(HOMA-IR)(SMD:-1.58;95CI:-2.20至-0.97,P<0.00001),白细胞介素-6(IL-6)(SMD:-1.31;95CI:-2.07至-0.55,P=0.0007),C反应蛋白(CRP)(SMD:-0.64;95CI:-1.21至-0.08,P=0.03),超重和肥胖儿童的瘦素(SMD:-3.43;95CI:-5.82至-1.05,P=0.005)。运动训练可增加脂联素水平(SMD:1.24;95CI:0.30~2.18,P=0.01),但不能改善肿瘤坏死因子-α(TNF-α)水平(SMD:-0.80;95CI:-1.77~0.18,P=0.11)。
结论:总之,运动疗法通过降低FBG水平改善葡萄糖代谢,FINS,HOMA-IR,以及通过降低IL-6,CRP水平改善炎症状态,瘦素,超重和肥胖儿童的脂联素水平升高。运动训练与TNF-α水平之间无统计学意义。应进行其他长期试验以探索这种治疗观点并确认这些结果。