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Abstract：
Type 2 diabetes (T2D) is a multifaceted and heterogeneous syndrome associated with complications such as hypertension, coronary artery disease, and notably, breast cancer (BC). The connection between T2D and BC is established through processes that involve insulin resistance, inflammation and other factors. Despite this comprehension the specific cellular and molecular mechanisms linking T2D to BC, especially through microRNAs (miRNAs), remain elusive. miRNAs are regulators of gene expression at the post-transcriptional level and have the function of regulating target genes by modulating various signaling pathways and biological processes. However, the signaling pathways and biological processes regulated by miRNAs that are associated with T2D and BC have not yet been elucidated. This review aims to identify dysregulated miRNAs in both T2D and BC, exploring potential signaling pathways and biological processes that collectively contribute to the development of BC.
摘要：
2型糖尿病（T2D）是与高血压等并发症相关的多方面和异质性综合征，冠状动脉疾病,尤其是,乳腺癌（BC）。T2D和BC之间的联系是通过涉及胰岛素抵抗的过程建立的，炎症和其他因素。尽管理解了将T2D与BC联系起来的特定细胞和分子机制，特别是通过microRNAs（miRNAs），仍然难以捉摸。miRNAs是转录后水平的基因表达调节因子,具有通过调节各种信号通路和生物过程调节靶基因的功能。然而,与T2D和BC相关的miRNA调节的信号通路和生物过程尚未阐明。这篇综述旨在鉴定T2D和BC中失调的miRNA，探索共同促进BC发展的潜在信号通路和生物过程。
