PDF(Pubmed)
Abstract：
UNASSIGNED: Osteoarthritis (OA) is a global musculoskeletal disorder that affects primarily the knee and hip joints without any FDA-approved disease-modifying therapies. Animal models are essential research tools in developing therapies for OA; many animal studies have provided data for the initiation of human clinical trials. Despite this, there is still a need for strategies to recapitulate the human experience using animal models to better develop treatments and understand pathogenesis. Since our last review on animal models of osteoarthritis in 2016, there have been exciting updates in OA research and models. The main purpose of this review is to update the latest animal models and key features of studies in OA research.
UNASSIGNED: We used our existing classification method and screened articles in PubMed and bibliographic search for animal OA models between 2016 and 2023. Relevant and high-cited articles were chosen for inclusion in this narrative review.
UNASSIGNED: Recent studies were analyzed and classified. We also identified ex vivo models as an area of ongoing research. Each animal model offers its own benefit in the study of OA and there are a full range of outcome measures that can be assessed. Despite the vast number of models, each has its drawbacks that have limited translating approved therapies for human use.
UNASSIGNED: Depending on the outcome measures and objective of the study, researchers should pick the best model for their work. There have been several exciting studies since 2016 that have taken advantage of regenerative engineering techniques to develop therapies and better understand OA.
UNASSIGNED: Osteoarthritis (OA) is a chronic debilitating disease without any cure that affects mostly the knee and hip joints and often results in surgical joint replacement. Cartilage protects the joint from mechanical forces and degrades with age or in response to injury. The many contributing causes of OA are still being investigated, and animals are used for preclinical research and to test potential new treatments. A single consensus OA animal model for preclinical studies is non-existent. In this article, we review the many animal models for OA and provide a much-needed update on studies and model development since 2016.
UNASSIGNED: We used our existing classification method and screened articles in PubMed and bibliographic search for animal OA models between 2016 and 2023. Relevant and high-cited articles were chosen for inclusion in this narrative review.
UNASSIGNED: Recent studies were analyzed and classified. We also identified ex vivo models as an area of ongoing research. Each animal model offers its own benefit in the study of OA and there are a full range of outcome measures that can be assessed. Despite the vast number of models, each has its drawbacks that have limited translating approved therapies for human use.
UNASSIGNED: Depending on the outcome measures and objective of the study, researchers should pick the best model for their work. There have been several exciting studies since 2016 that have taken advantage of regenerative engineering techniques to develop therapies and better understand OA.
UNASSIGNED: Osteoarthritis (OA) is a chronic debilitating disease without any cure that affects mostly the knee and hip joints and often results in surgical joint replacement. Cartilage protects the joint from mechanical forces and degrades with age or in response to injury. The many contributing causes of OA are still being investigated, and animals are used for preclinical research and to test potential new treatments. A single consensus OA animal model for preclinical studies is non-existent. In this article, we review the many animal models for OA and provide a much-needed update on studies and model development since 2016.
摘要：
骨关节炎（OA）是一种全球性的肌肉骨骼疾病，主要影响膝关节和髋关节，没有任何FDA批准的疾病改善疗法。动物模型是开发OA疗法的重要研究工具；许多动物研究为开始人体临床试验提供了数据。尽管如此,仍然需要使用动物模型来概括人类经验的策略，以更好地开发治疗方法和理解发病机制。自2016年我们对骨关节炎动物模型的回顾以来，OA研究和模型有了令人兴奋的更新。这篇综述的主要目的是更新OA研究中最新的动物模型和研究的关键特征。
■我们使用了我们现有的分类方法，并在PubMed和书目搜索中筛选了2016年至2023年动物OA模型的文章。相关和高引用的文章被选择纳入这篇叙述性综述。
■对最近的研究进行了分析和分类。我们还将离体模型确定为正在进行的研究领域。每种动物模型在OA的研究中都有自己的益处，并且可以评估各种结果指标。尽管有大量的模型，每个都有其缺点，有限翻译批准的用于人类使用的疗法。
■根据研究的结果指标和目标，研究人员应该为他们的工作选择最好的模型。自2016年以来，已经有几项令人兴奋的研究利用再生工程技术来开发治疗方法并更好地了解OA。
骨关节炎（OA）是一种慢性衰弱性疾病，无法治愈，主要影响膝关节和髋关节，并经常导致手术关节置换。软骨保护关节免受机械力的影响，并随着年龄或受伤而退化。OA的许多原因仍在调查中，和动物用于临床前研究和测试潜在的新疗法。用于临床前研究的单一共识OA动物模型是不存在的。在这篇文章中,我们回顾了许多OA动物模型,并提供了自2016年以来急需的最新研究和模型开发.
■我们使用了我们现有的分类方法，并在PubMed和书目搜索中筛选了2016年至2023年动物OA模型的文章。相关和高引用的文章被选择纳入这篇叙述性综述。
■对最近的研究进行了分析和分类。我们还将离体模型确定为正在进行的研究领域。每种动物模型在OA的研究中都有自己的益处，并且可以评估各种结果指标。尽管有大量的模型，每个都有其缺点，有限翻译批准的用于人类使用的疗法。
■根据研究的结果指标和目标，研究人员应该为他们的工作选择最好的模型。自2016年以来，已经有几项令人兴奋的研究利用再生工程技术来开发治疗方法并更好地了解OA。
骨关节炎（OA）是一种慢性衰弱性疾病，无法治愈，主要影响膝关节和髋关节，并经常导致手术关节置换。软骨保护关节免受机械力的影响，并随着年龄或受伤而退化。OA的许多原因仍在调查中，和动物用于临床前研究和测试潜在的新疗法。用于临床前研究的单一共识OA动物模型是不存在的。在这篇文章中,我们回顾了许多OA动物模型,并提供了自2016年以来急需的最新研究和模型开发.
