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Abstract：
Small regulatory RNAs (sRNAs) encapsulated in outer membrane vesicles (OMVs) are critical post-transcriptional regulators of gene expression in prokaryotic and eukaryotic organisms. OMVs are small spherical structures released by Gram-negative bacteria that serve as important vehicles for intercellular communication and can also play an important role in bacterial virulence and host-pathogen interactions. These molecules can interact with mRNAs or proteins and affect various cellular functions and physiological processes in the producing bacteria. This review aims to provide insight into the current understanding of sRNA localization to OMVs in Gram-negative bacteria and highlights the identification, characterization and functional implications of these encapsulated sRNAs. By examining the research gaps in this field, we aim to inspire further exploration and progress in investigating the potential therapeutic applications of OMV-encapsulated sRNAs in various diseases.
摘要：
封装在外膜囊泡（OMV）中的小调节RNA（sRNA）是原核和真核生物中基因表达的关键转录后调节因子。OMV是革兰氏阴性细菌释放的小球形结构，可作为细胞间通讯的重要载体，也可在细菌毒力和宿主-病原体相互作用中发挥重要作用。这些分子可以与mRNA或蛋白质相互作用，并影响生产细菌的各种细胞功能和生理过程。这篇综述旨在深入了解当前对革兰氏阴性细菌中sRNA定位到OMV的理解，并强调鉴定，这些包封的sRNA的表征和功能含义。通过考察这一领域的研究差距，我们的目标是在研究OMV封装的sRNAs在各种疾病中的潜在治疗应用方面激发进一步的探索和进展。
