PDF(Pubmed)
Abstract：
There is growing evidence that the pathogenesis of retinal diseases such as diabetic retinopathy (DR) and age-related macular degeneration (AMD) have a significant chronic inflammatory component. A vital part of the inflammatory cascade is through the activation of pattern recognition receptors (PRR) such as toll-like receptors (TLR). Here, we reviewed the past and current literature to ascertain the cumulative knowledge regarding the effect of TLRs on the development and progression of retinal diseases. There is burgeoning research demonstrating the relationship between TLRs and risk of developing retinal diseases, utilising a range of relevant disease models and a few large clinical investigations. The literature confirms that TLRs are involved in the development and progression of retinal diseases such as DR, AMD, and ischaemic retinopathy. Genetic polymorphisms in TLRs appear to contribute to the risk of developing AMD and DR. However, there are some inconsistencies in the published reports which require further elucidation. The evidence regarding TLR associations in retinal dystrophies including retinitis pigmentosa is limited. Based on the current evidence relating to the role of TLRs, combining anti-VEGF therapies with TLR inhibition may provide a longer-lasting treatment in some retinal vascular diseases.
摘要：
越来越多的证据表明，糖尿病性视网膜病变（DR）和年龄相关性黄斑变性（AMD）等视网膜疾病的发病机制具有明显的慢性炎症成分。炎性级联的重要部分是通过激活模式识别受体(PRR)如toll样受体(TLR)。这里,我们回顾了过去和目前的文献,以确定有关TLRs对视网膜疾病发生发展的影响的累积知识.有新兴的研究表明TLRs与视网膜疾病发展风险之间的关系，利用一系列相关疾病模型和一些大型临床研究。文献证实TLRs参与DR等视网膜疾病的发生发展,AMD,和缺血性视网膜病变.TLR中的遗传多态性似乎有助于发展AMD和DR的风险。然而,已发表的报告中有一些不一致之处，需要进一步阐明。关于包括色素性视网膜炎在内的视网膜营养不良中的TLR关联的证据是有限的。根据目前有关TLRs作用的证据,抗VEGF治疗与TLR抑制联合治疗可能为某些视网膜血管疾病提供更持久的治疗.
