PDF(Pubmed)
Abstract：
UNASSIGNED: Ureteral strictures (US) could lead to impaired kidney function, which was alleviated by ureteral reconstruction surgery. However, solitary kidney (SK) patients with US were more complicated to treat. This study aimed to evaluate the impact of reconstruction surgery on renal function based on estimated glomerular filtration rate (eGFR) in patients with SK.
UNASSIGNED: We retrospectively enrolled patients who underwent reconstruction surgery between April 2014 to March 2022. eGFR was measured pre- and postoperatively. The \'static renal function\' was defined as a change in eGFR of 20% or less at the last follow-up, and the \'worsening renal function group\' was defined as a decrease of greater than 20%.
UNASSIGNED: A total of 61 SK patients were involved. The success rate of ureteral reconstruction surgery was 90.16% (55/61). The median follow-up time was 20.8 months (range, 3.7-109.2 months). The median eGFR was 65.5 (range, 15.1-99.9) and 65.3 (range, 3.8-123.4) mL/min/1.73 m2 at the baseline and the last follow-up. No statistically significant difference in eGFR was observed between the preoperative baseline and last follow-up visits (P=0.58). However, in patients with baseline renal dysfunction [chronic kidney disease (CKD) stage 3-5], the eGFR significantly improved at the last follow-up compared to the baseline (P=0.02). Three patients developed a \'worsening renal function\' (4.92%). Besides, the systolic blood pressures (SBP) at follow-up significantly reduced compared to the preoperative baseline (P=0.002).
UNASSIGNED: Ureteral reconstruction surgery is an effective treatment to preserve renal function, which also achieves a high success rate and is associated with the reduction of SBP for SK patients with US.
UNASSIGNED: We retrospectively enrolled patients who underwent reconstruction surgery between April 2014 to March 2022. eGFR was measured pre- and postoperatively. The \'static renal function\' was defined as a change in eGFR of 20% or less at the last follow-up, and the \'worsening renal function group\' was defined as a decrease of greater than 20%.
UNASSIGNED: A total of 61 SK patients were involved. The success rate of ureteral reconstruction surgery was 90.16% (55/61). The median follow-up time was 20.8 months (range, 3.7-109.2 months). The median eGFR was 65.5 (range, 15.1-99.9) and 65.3 (range, 3.8-123.4) mL/min/1.73 m2 at the baseline and the last follow-up. No statistically significant difference in eGFR was observed between the preoperative baseline and last follow-up visits (P=0.58). However, in patients with baseline renal dysfunction [chronic kidney disease (CKD) stage 3-5], the eGFR significantly improved at the last follow-up compared to the baseline (P=0.02). Three patients developed a \'worsening renal function\' (4.92%). Besides, the systolic blood pressures (SBP) at follow-up significantly reduced compared to the preoperative baseline (P=0.002).
UNASSIGNED: Ureteral reconstruction surgery is an effective treatment to preserve renal function, which also achieves a high success rate and is associated with the reduction of SBP for SK patients with US.
摘要：
■输尿管狭窄（美国）可能导致肾功能受损，输尿管重建手术缓解了这种情况。然而,孤立肾（SK）患者的治疗更为复杂。本研究旨在根据SK患者的肾小球滤过率（eGFR）评估重建手术对肾功能的影响。
■我们回顾性纳入2014年4月至2022年3月期间接受重建手术的患者。术前和术后测量eGFR。“静态肾功能”定义为在最后一次随访时eGFR的变化为20％或更小，肾功能恶化组定义为下降超过20%。
■共纳入61例SK患者。输尿管重建手术成功率为90.16%(55/61)。中位随访时间为20.8个月(范围,3.7-109.2个月）。eGFR中位数为65.5(范围，15.1-99.9)和65.3(范围，在基线和最后一次随访时，3.8-123.4）mL/min/1.73m2。术前基线和末次随访之间的eGFR差异无统计学意义（P=0.58）。然而,在基线肾功能不全[慢性肾脏病（CKD）3-5期]的患者中，与基线相比,末次随访时eGFR显著改善(P=0.02).三名患者出现“肾功能恶化”（4.92％）。此外,随访时收缩压(SBP)较术前基线显著降低(P=0.002).
■输尿管重建手术是保护肾功能的有效治疗方法，这也获得了很高的成功率，并且与US患者的SBP降低有关。
■我们回顾性纳入2014年4月至2022年3月期间接受重建手术的患者。术前和术后测量eGFR。“静态肾功能”定义为在最后一次随访时eGFR的变化为20％或更小，肾功能恶化组定义为下降超过20%。
■共纳入61例SK患者。输尿管重建手术成功率为90.16%(55/61)。中位随访时间为20.8个月(范围,3.7-109.2个月）。eGFR中位数为65.5(范围，15.1-99.9)和65.3(范围，在基线和最后一次随访时，3.8-123.4）mL/min/1.73m2。术前基线和末次随访之间的eGFR差异无统计学意义（P=0.58）。然而,在基线肾功能不全[慢性肾脏病（CKD）3-5期]的患者中，与基线相比,末次随访时eGFR显著改善(P=0.02).三名患者出现“肾功能恶化”（4.92％）。此外,随访时收缩压(SBP)较术前基线显著降低(P=0.002).
■输尿管重建手术是保护肾功能的有效治疗方法，这也获得了很高的成功率，并且与US患者的SBP降低有关。
