PDF(Pubmed)
Abstract：
UNASSIGNED: To investigate the efficacy of liposomal prednisolone phosphate to mitigate the severity of proliferative vitreoretinopathy (PVR) in a minipig model of PVR.
UNASSIGNED: A total of 18 eyes of 9 minipigs underwent PVR induction surgically. Eyes were randomized equally into three groups: intravitreal injection of liposomal prednisolone phosphate (LPP), triamcinolone acetonide (TA), and controls. PVR severity was graded on fundoscopic examination using a modified version of the Silicon Study Classification System. Severe PVR was defined as grade 2-5 on this classification, and the proportion of eyes with retinal detachment from severe PVR, defined as retinal re-detachment, i.e., PVR grade 2-5, was compared between treatment and control groups.
UNASSIGNED: On day 28, five eyes (83.3%) in the control group were observed to have severe PVR. Within the LPP group, one (16.7%) eye developed retinal detachment due to severe PVR. Grade 0 PVR was observed in four (66.7%) eyes, grade 1 in one (16.7%) eye, and grade 5 in one (16.7%) eye. Within the TA group, grade 0 PVR was observed in four eyes (66.7%), grade 1 in two eyes (16.6%), and grade 5 in one (16.7%) eye. The difference in the proportion of eyes with severe PVR was significantly lower in the LPP group compared to controls at day 28 (16.7% vs 83.3%, p=0.02). There was no significant difference in the rate of severe PVR or median PVR grade between the liposomal prednisolone phosphate and triamcinolone acetonide groups.
UNASSIGNED: Liposomal prednisolone phosphate reduces the severity of PVR in a minipig model of PVR.
UNASSIGNED: A total of 18 eyes of 9 minipigs underwent PVR induction surgically. Eyes were randomized equally into three groups: intravitreal injection of liposomal prednisolone phosphate (LPP), triamcinolone acetonide (TA), and controls. PVR severity was graded on fundoscopic examination using a modified version of the Silicon Study Classification System. Severe PVR was defined as grade 2-5 on this classification, and the proportion of eyes with retinal detachment from severe PVR, defined as retinal re-detachment, i.e., PVR grade 2-5, was compared between treatment and control groups.
UNASSIGNED: On day 28, five eyes (83.3%) in the control group were observed to have severe PVR. Within the LPP group, one (16.7%) eye developed retinal detachment due to severe PVR. Grade 0 PVR was observed in four (66.7%) eyes, grade 1 in one (16.7%) eye, and grade 5 in one (16.7%) eye. Within the TA group, grade 0 PVR was observed in four eyes (66.7%), grade 1 in two eyes (16.6%), and grade 5 in one (16.7%) eye. The difference in the proportion of eyes with severe PVR was significantly lower in the LPP group compared to controls at day 28 (16.7% vs 83.3%, p=0.02). There was no significant difference in the rate of severe PVR or median PVR grade between the liposomal prednisolone phosphate and triamcinolone acetonide groups.
UNASSIGNED: Liposomal prednisolone phosphate reduces the severity of PVR in a minipig model of PVR.
摘要：
为了研究脂质体泼尼松龙磷酸盐在小型猪PVR模型中减轻增殖性玻璃体视网膜病变(PVR)严重程度的功效。
■共有18只眼的9只小型猪接受了手术诱导PVR。眼睛被随机分为三组：玻璃体内注射脂质体磷酸泼尼松龙（LPP），曲安奈德(TA),和控制。使用改良版本的硅研究分类系统在眼底镜检查上对PVR严重程度进行分级。重度PVR在此分类中被定义为2-5级，重度PVR视网膜脱离的比例，定义为视网膜再脱离,即，在治疗组和对照组之间比较PVR2-5级。
■在第28天,观察到对照组中的5只眼睛(83.3%)具有严重的PVR。在LPP组中，1只(16.7%)眼因重度PVR出现视网膜脱离。在四只(66.7%)眼睛中观察到0级PVR，一级(16.7%)眼睛，一只眼睛（16.7％）为5级。在TA组中，在四只眼睛中观察到0级PVR（66.7％），两只眼睛一年级（16.6%），一只眼睛（16.7％）为5级。在第28天，与对照组相比，LPP组严重PVR的眼睛比例差异显着降低（16.7％vs83.3％，p=0.02)。脂质体磷酸泼尼松龙和曲安奈德组之间的严重PVR率或中位PVR等级没有显着差异。
■脂质体磷酸泼尼松龙降低了PVR的小型猪模型中PVR的严重程度。
■共有18只眼的9只小型猪接受了手术诱导PVR。眼睛被随机分为三组：玻璃体内注射脂质体磷酸泼尼松龙（LPP），曲安奈德(TA),和控制。使用改良版本的硅研究分类系统在眼底镜检查上对PVR严重程度进行分级。重度PVR在此分类中被定义为2-5级，重度PVR视网膜脱离的比例，定义为视网膜再脱离,即，在治疗组和对照组之间比较PVR2-5级。
■在第28天,观察到对照组中的5只眼睛(83.3%)具有严重的PVR。在LPP组中，1只(16.7%)眼因重度PVR出现视网膜脱离。在四只(66.7%)眼睛中观察到0级PVR，一级(16.7%)眼睛，一只眼睛（16.7％）为5级。在TA组中，在四只眼睛中观察到0级PVR（66.7％），两只眼睛一年级（16.6%），一只眼睛（16.7％）为5级。在第28天，与对照组相比，LPP组严重PVR的眼睛比例差异显着降低（16.7％vs83.3％，p=0.02)。脂质体磷酸泼尼松龙和曲安奈德组之间的严重PVR率或中位PVR等级没有显着差异。
■脂质体磷酸泼尼松龙降低了PVR的小型猪模型中PVR的严重程度。
