%0 Journal Article
%T Evaluation of a steroid delivery system to mitigate the severity of proliferative vitreoretinopathy in a minipig model.
%A Wong CW
%A Cheung N
%A Howden JS
%A Busoy JMF
%A Sim S
%A Lim J
%A Ho C
%A Veluchamy AB
%A Storm G
%A Wong TT
%J Front Ophthalmol (Lausanne)
%V 3
%N 0
%D 2023
%M 38982997
暂无%R 10.3389/fopht.2023.1222689
%X <B>UNASSIGNED: </B>To investigate the efficacy of liposomal prednisolone phosphate to mitigate the severity of proliferative vitreoretinopathy (PVR) in a minipig model of PVR.<BR><B>UNASSIGNED: </B>A total of 18 eyes of 9 minipigs underwent PVR induction surgically. Eyes were randomized equally into three groups: intravitreal injection of liposomal prednisolone phosphate (LPP), triamcinolone acetonide (TA), and controls. PVR severity was graded on fundoscopic examination using a modified version of the Silicon Study Classification System. Severe PVR was defined as grade 2-5 on this classification, and the proportion of eyes with retinal detachment from severe PVR, defined as retinal re-detachment, i.e., PVR grade 2-5, was compared between treatment and control groups.<BR><B>UNASSIGNED: </B>On day 28, five eyes (83.3%) in the control group were observed to have severe PVR. Within the LPP group, one (16.7%) eye developed retinal detachment due to severe PVR. Grade 0 PVR was observed in four (66.7%) eyes, grade 1 in one (16.7%) eye, and grade 5 in one (16.7%) eye. Within the TA group, grade 0 PVR was observed in four eyes (66.7%), grade 1 in two eyes (16.6%), and grade 5 in one (16.7%) eye. The difference in the proportion of eyes with severe PVR was significantly lower in the LPP group compared to controls at day 28 (16.7% vs 83.3%, p=0.02). There was no significant difference in the rate of severe PVR or median PVR grade between the liposomal prednisolone phosphate and triamcinolone acetonide groups.<BR><B>UNASSIGNED: </B>Liposomal prednisolone phosphate reduces the severity of PVR in a minipig model of PVR.