PDF(Pubmed)
Abstract：
BACKGROUND: Appropriate drug prescribing in the pediatric population is challenging, given this age group\'s unique pharmacokinetics. This has inevitably led to a high incidence of adverse drug reactions in this population. To address this issue, the Pediatric Pharmacy Association (PPA) compiled a list of 67 drugs that are inappropriately used in the pediatric population called the Key Potentially Inappropriate Drugs \"KIDs list\".
OBJECTIVE: To estimate the prevalence of potentially inappropriate medications (PIM) use in pediatric wards based on the KIDs list criteria.
METHODS: A retrospective observational study was conducted and included pediatric patients who were admitted to five pediatric wards during 3 years (2019-2021). The drugs in the KIDs list were matched to the hospital formulary and 11 matched drugs were included in the study. For each individual drug, the patient\'s electronic file was reviewed to determine the prescription appropriateness according to the KIDs list criteria.
RESULTS: Among 3,166 pediatric patients admitted to pediatric wards, a total of 415 patients received a PIM listed in the KIDs list. The mean age was 8.6 (± 4.9) years old, and 60.0% (n = 251/415) were males. The overall prevalence of PIM use was 13.0% (n = 415/3166). Among the prescribed PIM, metoclopramide was the most commonly prescribed PIM 42.8% (n = 178/415), followed by tramadol 37.6% (n = 156/415).
CONCLUSIONS: Given the high prevalence of inappropriate medication use in the pediatric wards, future research on strategies and interventions should be recommended to limit the use of PIMs and provide safer alternatives for the pediatric population.
OBJECTIVE: To estimate the prevalence of potentially inappropriate medications (PIM) use in pediatric wards based on the KIDs list criteria.
METHODS: A retrospective observational study was conducted and included pediatric patients who were admitted to five pediatric wards during 3 years (2019-2021). The drugs in the KIDs list were matched to the hospital formulary and 11 matched drugs were included in the study. For each individual drug, the patient\'s electronic file was reviewed to determine the prescription appropriateness according to the KIDs list criteria.
RESULTS: Among 3,166 pediatric patients admitted to pediatric wards, a total of 415 patients received a PIM listed in the KIDs list. The mean age was 8.6 (± 4.9) years old, and 60.0% (n = 251/415) were males. The overall prevalence of PIM use was 13.0% (n = 415/3166). Among the prescribed PIM, metoclopramide was the most commonly prescribed PIM 42.8% (n = 178/415), followed by tramadol 37.6% (n = 156/415).
CONCLUSIONS: Given the high prevalence of inappropriate medication use in the pediatric wards, future research on strategies and interventions should be recommended to limit the use of PIMs and provide safer alternatives for the pediatric population.
摘要：
背景：在儿科人群中适当的药物处方具有挑战性，考虑到这个年龄组独特的药代动力学。这不可避免地导致了该人群中药物不良反应的高发生率。为了解决这个问题，儿科药学协会(PPA)编制了67种在儿科人群中不适当使用的药物清单,称为“关键潜在不适当药物清单”.
目的：根据KID列表标准估计儿科病房中潜在不适当药物（PIM）使用的患病率。
方法：进行了一项回顾性观察性研究，包括在3年内（2019-2021年）入住五个儿科病房的儿科患者。KIDs列表中的药物与医院处方集匹配，研究中包括11种匹配的药物。对于每种药物，我们根据KIDs列表标准审查了患者的电子文件,以确定处方是否合适.
结果：在儿科病房收治的3166名儿科患者中，共有415例患者接受了KID列表中列出的PIM.平均年龄8.6(±4.9)岁,60.0%(n=251/415)为男性。PIM使用的总体患病率为13.0%(n=415/3166)。在规定的PIM中，甲氧氯普胺是最常用的PIM42.8%(n=178/415)，其次是曲马多37.6%(n=156/415)。
结论：鉴于儿科病房中不适当用药的患病率很高，应建议对策略和干预措施进行未来研究,以限制PIMs的使用,并为儿科人群提供更安全的替代方案.
目的：根据KID列表标准估计儿科病房中潜在不适当药物（PIM）使用的患病率。
方法：进行了一项回顾性观察性研究，包括在3年内（2019-2021年）入住五个儿科病房的儿科患者。KIDs列表中的药物与医院处方集匹配，研究中包括11种匹配的药物。对于每种药物，我们根据KIDs列表标准审查了患者的电子文件,以确定处方是否合适.
结果：在儿科病房收治的3166名儿科患者中，共有415例患者接受了KID列表中列出的PIM.平均年龄8.6(±4.9)岁,60.0%(n=251/415)为男性。PIM使用的总体患病率为13.0%(n=415/3166)。在规定的PIM中，甲氧氯普胺是最常用的PIM42.8%(n=178/415)，其次是曲马多37.6%(n=156/415)。
结论：鉴于儿科病房中不适当用药的患病率很高，应建议对策略和干预措施进行未来研究,以限制PIMs的使用,并为儿科人群提供更安全的替代方案.
