PDF(Pubmed)
Abstract：
Tobacco smoke exposure has been demonstrated to impede bone remodeling and diminish bone density, yet research regarding its correlation with parathyroid hormone (PTH) remains limited. This study aims to investigate the relationship between tobacco smoke exposure and serum PTH levels in adults aged 20 years and older. This study included 7,641 participants from two cycles of the National Health and Nutrition Examination Survey (NHANES, United States, 2003- 2006). Reflect tobacco smoke exposure through serum cotinine levels, and use an adjusted weighted multivariate linear regression model to test the independent linear relationship between serum cotinine and PTH. Stratified analysis was conducted to validate the sensitivity of the conclusions. Smooth curve fitting and threshold effect analysis were performed to assess the non-linear relationship. After comprehensive adjustment using weighted multivariate regression analysis, a negative correlation was found between serum cotinine and PTH levels. The interaction p-values in subgroup analyses were all greater than 0.05. Moreover, smooth curve fitting indicated a non-linear relationship between serum cotinine and PTH, with a turning point observed. Our research indicates that tobacco smoke exposure is negatively correlated and independent of serum parathyroid hormone levels, indicating that long-term tobacco smoke exposure may lead to parathyroid dysfunction in adults.
摘要：
烟草烟雾暴露已被证明会阻碍骨骼重塑并减少骨密度，然而,关于其与甲状旁腺激素(PTH)相关性的研究仍然有限.本研究旨在探讨20岁及以上成人烟草烟雾暴露与血清PTH水平之间的关系。这项研究包括来自国家健康和营养调查的两个周期的7,641名参与者(NHANES，美国,2003-2006年)。通过血清可替宁水平反映烟草烟雾暴露，并采用调整后的加权多元线性回归模型检验血清可替宁与PTH的独立线性关系。进行了分层分析，以验证结论的敏感性。进行平滑曲线拟合和阈值效应分析以评估非线性关系。在使用加权多元回归分析进行综合调整后，血清可替宁与PTH水平呈负相关。亚组分析中的相互作用p值均大于0.05。此外，平滑曲线拟合表明血清可替宁与PTH呈非线性关系，观察到一个转折点。我们的研究表明，烟草烟雾暴露与血清甲状旁腺激素水平呈负相关，并且与血清甲状旁腺激素水平无关。表明长期接触烟草烟雾可能导致成人甲状旁腺功能障碍。
