PDF(Pubmed)
Abstract：
Dietary antioxidants may have beneficial effects on bone health, but it remains uncertain in children and adolescents. This study investigates the association of composite dietary antioxidant index (CDAI) with bone mineral density (BMD) in children and adolescents aged 8-19 years from the National Health and Nutrition Examination Survey (NHANES) 2007-2010. The study assessed the relationship between CDAI and BMD in 2994 individuals aged 8-19 years (average age 13.48 ± 3.32 years) from the NHANES 2007-2010. Multivariate linear regression analyses were utilized to detect the association between CDAI and total spine, femur neck, and total femur BMD, adjusting for confounders including age, race/ethnicity, sex, poverty income ratio (PIR), body mass index (BMI), serum phosphorus and calcium. Stratified analyses and interaction tests were performed to examine the stability of the results. The weighted characteristics showed that subjects in the fourth CDAI quartile were more likely to be older, men, and Non-Hispanic White. They have higher values of serum total calcium and phosphorus. After adjusting all confounders, CDAI was positively associated with the total spine (β = 0.0031 95% CI 0.0021-0.0040), total femur (β = 0.0039 95% CI 0.0028-0.0049), and femur neck BMD (β = 0.0031 95% CI 0.0021-0.0040) in children and adolescents. Furthermore, we found no interaction effects between different race/ethnicity, age, and sex groups. Our findings suggest that dietary intake of multiple antioxidants was positively associated with BMD in children and adolescents. These findings provide valuable evidence for improving bone health in the early stages of life. However, more prospective studies are required to validate our findings and their causal relationship.
摘要：
膳食抗氧化剂可能对骨骼健康有益，但在儿童和青少年中仍然不确定。这项研究调查了2007-2010年国家健康与营养调查（NHANES）中8-19岁儿童和青少年的复合膳食抗氧化剂指数（CDAI）与骨密度（BMD）的关系。该研究评估了NHANES2007-2010年2994名年龄在8-19岁（平均年龄13.48±3.32岁）的个体CDAI和BMD之间的关系。多元线性回归分析用于检测CDAI与全脊柱之间的关联。股骨颈,和总股骨BMD,调整混杂因素，包括年龄，种族/民族,性别,贫困收入比(PIR)，体重指数（BMI），血清磷和钙。进行了分层分析和相互作用测试以检查结果的稳定性。加权特征显示，第四个CDAI四分位数的受试者年龄较大，男人,非西班牙裔白人。它们具有较高的血清总钙和磷的值。在调整了所有混杂因素后，CDAI与全脊柱呈正相关(β=0.003195%CI0.0021-0.0040),总股骨（β=0.003995%CI0.0028-0.0049），儿童和青少年股骨颈骨密度(β=0.003195%CI0.0021-0.0040)。此外，我们发现不同种族/民族之间没有相互作用的影响，年龄,和性团体。我们的发现表明，在儿童和青少年中，饮食摄入多种抗氧化剂与BMD呈正相关。这些发现为改善生命早期的骨骼健康提供了有价值的证据。然而,需要更多的前瞻性研究来验证我们的研究结果及其因果关系.
