PDF(Pubmed)
Abstract：
Primary axillary hyperhidrosis is an idiopathic disorder that creates severe psycho-social burden due to excessive uncontrolled sweating. Various therapeutic agents have been described, but each has its own limitations. The use of fractional microneedling radiofrequency has emerged lately with promising results. This study aimed to determine the efficacy and safety of fractional microneedle radiofrequency in comparison to Botulinum toxin-A (BT-A) in patients with primary axillary hyperhidrosis. In this randomized controlled clinical trial, 20 patients (40 sides) were randomized to either fractional microneedle radiofrequency (4 sessions at 3-week intervals) or BT-A (single session), where each side received one of the treatment modalities. Efficacy was measured at 3, 6 and 12 months using Minor\'s starch iodine test, HDSS score, Hqol questionnaire, and patient satisfaction. Fractional microneedle radiofrequency, although showed moderate efficacy, is inferior to BT-A regarding longitudinal efficacy at 12 months, as well as patients\' satisfaction. Both treatment modalities showed to be equally safe, but fractional microneedle radiofrequency procedure was substantially more painful. In conclusion, fractional microneedle radiofrequency does not offer a better substitute to BT-A in primary axillary hyperhidrosis. BT-A shows higher efficacy, is less painful, less expensive, and needs a smaller number of sessions.
摘要：
原发性腋窝多汗症是一种特发性疾病，由于过度不受控制的出汗而造成严重的心理社会负担。已经描述了各种治疗剂,但每个都有自己的局限性。最近出现了分数微针射频的使用，并取得了有希望的结果。这项研究旨在确定与A型肉毒杆菌毒素（BT-A）相比，局部微针射频在原发性腋窝多汗症患者中的疗效和安全性。在这项随机对照临床试验中，20名患者（40侧）被随机分为部分微针射频（间隔3周进行4次治疗）或BT-A（单次治疗），双方都接受了一种治疗方式。使用Minor's淀粉碘试验在3、6和12个月测量疗效，HDSS评分,Hqol问卷，患者满意度。分数微针射频，虽然显示中等疗效，12个月时纵向疗效不如BT-A，以及患者的满意度。两种治疗方式显示同样安全，但是分数微针射频手术更痛苦。总之,在原发性腋窝多汗症中，分数微针射频不能为BT-A提供更好的替代品。BT-A显示更高的疗效，不那么痛苦，更便宜，并且需要较少的会话。
