PDF(Pubmed)
Abstract：
Lesions of incomplete retinal pigment epithelium and outer retinal atrophy (iRORA) are associated with disease progression in age-related macular degeneration. However, the corresponding functional impact of these precursor lesions is unknown.We present a cross-sectional study of four patients employing clinical-grade MAIA (stimulus size: 0.43°, ~125 µm) and adaptive optics scanning light ophthalmoscope (AOSLO, stimulus size 0.07°, ~20 µm) based microperimetry (MP) to assess the specific impact of iRORA lesions on retinal sensitivity.AOSLO imaging showed overall reduced photoreceptor reflectivity and patches of hyporeflective regions at drusen with interspersed hyper-reflective foci in iRORA regions. MAIA-MP yielded an average retinal sensitivity loss of -7.3±3.1 dB at iRORA lesions compared with the in-eye control. With AOSLO-MP, the corresponding sensitivity loss was 20.1±4.8 dB.We demonstrated that iRORA lesions are associated with a severe impairment in retinal sensitivity. Larger cohort studies will be necessary to validate our findings.
摘要：
不完全视网膜色素上皮和外部视网膜萎缩（iRORA）的病变与年龄相关性黄斑变性的疾病进展有关。然而,这些前兆病变的相应功能影响尚不清楚.我们对四名采用临床级MAIA的患者进行了横断面研究（刺激大小：0.43°，~125µm)和自适应光学扫描光检眼镜(AOSLO，刺激大小0.07°，〜20µm）基于微视野法（MP），以评估iRORA病变对视网膜敏感性的特定影响。AOSLO成像显示光感受器反射率总体降低，玻璃疣处的低反射区域斑块与iRORA区域中散布的高反射焦点。与眼内对照相比，MAIA-MP在iRORA病变处的平均视网膜敏感性损失为-7.3±3.1dB。有了AOSLO-MP,相应的灵敏度损失为20.1±4.8dB。我们证明iRORA病变与视网膜敏感性的严重损害有关。更大规模的队列研究将是必要的，以验证我们的发现。
