PDF(Pubmed)
Abstract：
HIV Pre-Exposure Pophylaxis (PrEP) is provided free of charge by the Brazilian national health system. Though effective in preventing HIV infection, little is known about its impact on the health-related Quality of Life (QoL) of users.
The present study aimed at assessing the impact of PrEP on the QoL of its users.
Prospective cohort study with 114 HIV-negative participants aged 18 years or older. Participants\' QoL was assessed before starting PrEP and after 7 months of use, using the self-responsive WHOQOL-bref questionnaire. Sociodemographic and behavioral aspects were described and the Wilcoxon signed-rank test with p ≤ 0.05 was considered statistically significant.
Improvement was seen in QoL scores for the environment domain (p = 0.02), which addresses feeling of physical safety, access to information and health services, and participation in leisure activities. Furthermore, participants reported improved satisfaction with their sex life, when questioned about the social relationships domain. There was no statistically significant change in the global QoL score, in the global health score, in the physical and psychological domains, nor in the total score for the social relationships domain. As for their socio-demographic profile, most participants were white and highly educated young cisgender men who have sex with men. 76.3% had unprotected sex in the 3 months before starting PrEP. 60.5% had reported substance use: marijuana (42.1%), club drugs (35.1%), and poppers (20.2%).
This study unveiled that PrEP benefited our cohort beyond its effectiveness in preventing HIV infection, having improved environmental aspects of QoL and self-satisfaction with sex life.
The present study aimed at assessing the impact of PrEP on the QoL of its users.
Prospective cohort study with 114 HIV-negative participants aged 18 years or older. Participants\' QoL was assessed before starting PrEP and after 7 months of use, using the self-responsive WHOQOL-bref questionnaire. Sociodemographic and behavioral aspects were described and the Wilcoxon signed-rank test with p ≤ 0.05 was considered statistically significant.
Improvement was seen in QoL scores for the environment domain (p = 0.02), which addresses feeling of physical safety, access to information and health services, and participation in leisure activities. Furthermore, participants reported improved satisfaction with their sex life, when questioned about the social relationships domain. There was no statistically significant change in the global QoL score, in the global health score, in the physical and psychological domains, nor in the total score for the social relationships domain. As for their socio-demographic profile, most participants were white and highly educated young cisgender men who have sex with men. 76.3% had unprotected sex in the 3 months before starting PrEP. 60.5% had reported substance use: marijuana (42.1%), club drugs (35.1%), and poppers (20.2%).
This study unveiled that PrEP benefited our cohort beyond its effectiveness in preventing HIV infection, having improved environmental aspects of QoL and self-satisfaction with sex life.
摘要：
背景：艾滋病毒暴露前过敏反应（PrEP）由巴西国家卫生系统免费提供。虽然能有效预防HIV感染，它对用户健康相关生活质量(QoL)的影响知之甚少。
目的：本研究旨在评估PrEP对用户QoL的影响。
方法：对114名18岁或以上的HIV阴性参与者进行前瞻性队列研究。在开始使用PrEP之前和使用7个月后评估参与者的QoL，使用自我响应的WHOQOL-BREF问卷。描述了社会人口统计学和行为方面，p≤0.05的Wilcoxon符号秩检验被认为具有统计学意义。
结果：环境领域的QoL评分有所改善（p=0.02），解决身体安全感，获取信息和卫生服务，参与休闲活动。此外，参与者报告说他们对性生活的满意度有所提高，当被问及社会关系领域时。全球QoL评分没有统计学上的显著变化，在全球健康评分中，在生理和心理领域，在社会关系领域的总分中也是如此。至于他们的社会人口统计特征，大多数参与者是白人和受过高等教育的年轻男性，他们与男性发生性关系。76.3％的人在开始PrEP之前的3个月内没有保护性行为。60.5%的人报告使用了大麻(42.1%)，俱乐部毒品(35.1%),和poppers(20.2%)。
结论：这项研究揭示了PrEP使我们的队列受益，而不仅仅是其预防HIV感染的有效性，改善了生活质量的环境方面和对性生活的自我满意度。
目的：本研究旨在评估PrEP对用户QoL的影响。
方法：对114名18岁或以上的HIV阴性参与者进行前瞻性队列研究。在开始使用PrEP之前和使用7个月后评估参与者的QoL，使用自我响应的WHOQOL-BREF问卷。描述了社会人口统计学和行为方面，p≤0.05的Wilcoxon符号秩检验被认为具有统计学意义。
结果：环境领域的QoL评分有所改善（p=0.02），解决身体安全感，获取信息和卫生服务，参与休闲活动。此外，参与者报告说他们对性生活的满意度有所提高，当被问及社会关系领域时。全球QoL评分没有统计学上的显著变化，在全球健康评分中，在生理和心理领域，在社会关系领域的总分中也是如此。至于他们的社会人口统计特征，大多数参与者是白人和受过高等教育的年轻男性，他们与男性发生性关系。76.3％的人在开始PrEP之前的3个月内没有保护性行为。60.5%的人报告使用了大麻(42.1%)，俱乐部毒品(35.1%),和poppers(20.2%)。
结论：这项研究揭示了PrEP使我们的队列受益，而不仅仅是其预防HIV感染的有效性，改善了生活质量的环境方面和对性生活的自我满意度。
