Abstract：
This study aimed to examine joint trajectories of pain, depression and frailty and their associations with adverse outcomes. Four waves of national data from the China Health and Retirement Longitudinal Study (CHARLS 2011-2018) were used, involving 4217 participants aged ≥60 years. Joint trajectories were fit using parallel-process latent class growth analysis, and their associations with adverse outcomes were evaluated using modified Poisson regression. Four joint trajectories were identified. Compared with most favorable group, other three joint trajectory groups had higher risk of functional disability and hospitalization. Slowly progressive pain, depression and frailty and persistent combination of pain, depression and frailty were also associated with cognitive decline, while slowly reduced pain and depression but persistent frailty was associated with all-cause mortality. The findings highlight unique characteristics and health impacts of concurrent changes in pain, depression and frailty over time, implicating the integrated physical and psychological care for older adults.
摘要：
这项研究旨在检查疼痛的关节轨迹，抑郁和虚弱及其与不良结局的关系。使用了来自中国健康与退休纵向研究(CHARLS2011-2018)的四波国家数据，涉及4217名年龄≥60岁的参与者。使用并行处理潜在类增长分析拟合联合轨迹，并使用改良Poisson回归对其与不良结局的关联进行评估.确定了四个联合轨迹。与最有利的群体相比，其他3个联合轨迹组的功能性残疾和住院风险较高.缓慢进行性疼痛，抑郁和虚弱以及持续的疼痛组合，抑郁和虚弱也与认知能力下降有关，虽然疼痛和抑郁缓慢减轻，但持续虚弱与全因死亡率相关。研究结果突出了疼痛同时变化的独特特征和健康影响，随着时间的推移抑郁和虚弱，涉及对老年人的综合身体和心理护理。
