PDF(Pubmed)
Abstract：
BACKGROUND: The escalating use of complementary and alternative medicine (CAM) raises concerns, particularly among geriatric patients taking multiple medications. Notably, the doubled chance of major drug interactions between prescription and over-the-counter (OTC) drugs in older adults underscores the need for further research. This study aimed to evaluate clinically significant CAM and prescription medication interactions in a geriatric clinic, emphasizing the growing importance of understanding CAM implications in health care.
METHODS: A 2-year cross-sectional study, approved by the Institutional Review Board, enrolled 420 participants aged 65 and older from a geriatric primary care clinic. Participants completed a survey, and pharmacy students conducted chart reviews to evaluate potential CAM products and prescription medication interactions.
RESULTS: Among the 420 participants-who were predominantly White females and who were taking supplements, OTC medications, or both-15.6% experienced potential drug interactions. Ginkgo biloba, garlic, and calcium were common contributors to major, moderate, and minor interactions, respectively, among supplements. Meanwhile, ibuprofen was among the contributors to major and moderate interactions among OTC medications. Most supplements and OTC medications were disclosed to health care professionals. However, there was a lack of investigation by health care professionals regarding CAM use, emphasizing a discrepancy between patient-reported and physician-inquired CAM usage.
CONCLUSIONS: This study highlighted the significant use of CAM and/or OTC medications, particularly among vulnerable older adults, revealing a concerning 15.6% rate of potential drug interactions. The findings emphasized the need for awareness among health care practitioners and standardized CAM surveys to enhance accuracy and patient safety.
METHODS: A 2-year cross-sectional study, approved by the Institutional Review Board, enrolled 420 participants aged 65 and older from a geriatric primary care clinic. Participants completed a survey, and pharmacy students conducted chart reviews to evaluate potential CAM products and prescription medication interactions.
RESULTS: Among the 420 participants-who were predominantly White females and who were taking supplements, OTC medications, or both-15.6% experienced potential drug interactions. Ginkgo biloba, garlic, and calcium were common contributors to major, moderate, and minor interactions, respectively, among supplements. Meanwhile, ibuprofen was among the contributors to major and moderate interactions among OTC medications. Most supplements and OTC medications were disclosed to health care professionals. However, there was a lack of investigation by health care professionals regarding CAM use, emphasizing a discrepancy between patient-reported and physician-inquired CAM usage.
CONCLUSIONS: This study highlighted the significant use of CAM and/or OTC medications, particularly among vulnerable older adults, revealing a concerning 15.6% rate of potential drug interactions. The findings emphasized the need for awareness among health care practitioners and standardized CAM surveys to enhance accuracy and patient safety.
摘要：
背景：补充和替代医学（CAM）的使用不断增加引起了人们的关注，特别是在服用多种药物的老年患者中。值得注意的是,在老年人中,处方药和非处方药(OTC)之间主要药物相互作用的可能性增加了一倍,这凸显了进一步研究的必要性.这项研究旨在评估临床上重要的CAM和处方药物的相互作用在老年诊所，强调理解CAM在医疗保健中的意义越来越重要。
方法：一项为期2年的横断面研究，经机构审查委员会批准，从老年初级保健诊所纳入420名65岁及以上的参与者.参与者完成了一项调查，和药学学生进行图表审查，以评估潜在的CAM产品和处方药物的相互作用。
结果：在420名参与者中，主要是白人女性，正在服用补充剂，OTC药物,或两者-15.6%经历了潜在的药物相互作用。银杏,大蒜，大蒜钙是主要的共同贡献者，中度,和微小的互动，分别,在补品中。同时,布洛芬是OTC药物之间主要和中度相互作用的贡献者之一。大多数补充剂和OTC药物都向医疗保健专业人员披露。然而,卫生保健专业人员缺乏关于CAM使用的调查，强调患者报告和医生询问的CAM使用之间的差异。
结论：本研究强调了CAM和/或OTC药物的大量使用，特别是在脆弱的老年人中，揭示了潜在药物相互作用的15.6%。调查结果强调了医疗保健从业人员和标准化CAM调查的意识，以提高准确性和患者安全性。
方法：一项为期2年的横断面研究，经机构审查委员会批准，从老年初级保健诊所纳入420名65岁及以上的参与者.参与者完成了一项调查，和药学学生进行图表审查，以评估潜在的CAM产品和处方药物的相互作用。
结果：在420名参与者中，主要是白人女性，正在服用补充剂，OTC药物,或两者-15.6%经历了潜在的药物相互作用。银杏,大蒜，大蒜钙是主要的共同贡献者，中度,和微小的互动，分别,在补品中。同时,布洛芬是OTC药物之间主要和中度相互作用的贡献者之一。大多数补充剂和OTC药物都向医疗保健专业人员披露。然而,卫生保健专业人员缺乏关于CAM使用的调查，强调患者报告和医生询问的CAM使用之间的差异。
结论：本研究强调了CAM和/或OTC药物的大量使用，特别是在脆弱的老年人中，揭示了潜在药物相互作用的15.6%。调查结果强调了医疗保健从业人员和标准化CAM调查的意识，以提高准确性和患者安全性。
