PDF(Pubmed)
Abstract：
UNASSIGNED: Air pollution is associated with structural brain changes, disruption of neurogenesis, and neurodevelopmental disorders. The association between prenatal exposure to ambient air pollution and risk of cerebral palsy (CP), which is the most common motor disability in childhood, has not been thoroughly investigated.
UNASSIGNED: To evaluate the associations between prenatal residential exposure to ambient air pollution and risk of CP among children born at term gestation in a population cohort in Ontario, Canada.
UNASSIGNED: Population-based cohort study in Ontario, Canada using linked, province-wide health administrative databases. Participants were singleton full term births (≥37 gestational weeks) born in Ontario hospitals between April 1, 2002, and March 31, 2017. Data were analyzed from January to December 2022.
UNASSIGNED: Weekly average concentrations of ambient fine particulate matter with a diameter 2.5 μm (PM2.5) or smaller, nitrogen dioxide (NO2), and ozone (O3) during pregnancy assigned by maternal residence reported at delivery from satellite-based estimates and ground-level monitoring data.
UNASSIGNED: CP cases were ascertained by a single inpatient hospitalization diagnosis or at least 2 outpatient diagnoses for children from birth to age 18 years.
UNASSIGNED: The present study included 1 587 935 mother-child pairs who reached term gestation, among whom 3170 (0.2%) children were diagnosed with CP. The study population had a mean (SD) maternal age of 30.1 (5.6) years and 811 745 infants (51.1%) were male. A per IQR increase (2.7 μg/m3) in prenatal ambient PM2.5 concentration was associated with a cumulative hazard ratio (CHR) of 1.12 (95% CI, 1.03-1.21) for CP. The CHR in male infants (1.14; 95% CI, 1.02-1.26) was higher compared with the CHR in female infants (1.08; 95% CI, 0.96-1.22). No specific window of susceptibility was found for prenatal PM2.5 exposure and CP in the study population. No associations or windows of susceptibility were found for prenatal NO2 or O3 exposure and CP risk.
UNASSIGNED: In this large cohort study of singleton full term births in Canada, prenatal ambient PM2.5 exposure was associated with an increased risk of CP in offspring. Further studies are needed to explore this association and its potential biological pathways, which could advance the identification of environmental risk factors of CP in early life.
UNASSIGNED: To evaluate the associations between prenatal residential exposure to ambient air pollution and risk of CP among children born at term gestation in a population cohort in Ontario, Canada.
UNASSIGNED: Population-based cohort study in Ontario, Canada using linked, province-wide health administrative databases. Participants were singleton full term births (≥37 gestational weeks) born in Ontario hospitals between April 1, 2002, and March 31, 2017. Data were analyzed from January to December 2022.
UNASSIGNED: Weekly average concentrations of ambient fine particulate matter with a diameter 2.5 μm (PM2.5) or smaller, nitrogen dioxide (NO2), and ozone (O3) during pregnancy assigned by maternal residence reported at delivery from satellite-based estimates and ground-level monitoring data.
UNASSIGNED: CP cases were ascertained by a single inpatient hospitalization diagnosis or at least 2 outpatient diagnoses for children from birth to age 18 years.
UNASSIGNED: The present study included 1 587 935 mother-child pairs who reached term gestation, among whom 3170 (0.2%) children were diagnosed with CP. The study population had a mean (SD) maternal age of 30.1 (5.6) years and 811 745 infants (51.1%) were male. A per IQR increase (2.7 μg/m3) in prenatal ambient PM2.5 concentration was associated with a cumulative hazard ratio (CHR) of 1.12 (95% CI, 1.03-1.21) for CP. The CHR in male infants (1.14; 95% CI, 1.02-1.26) was higher compared with the CHR in female infants (1.08; 95% CI, 0.96-1.22). No specific window of susceptibility was found for prenatal PM2.5 exposure and CP in the study population. No associations or windows of susceptibility were found for prenatal NO2 or O3 exposure and CP risk.
UNASSIGNED: In this large cohort study of singleton full term births in Canada, prenatal ambient PM2.5 exposure was associated with an increased risk of CP in offspring. Further studies are needed to explore this association and its potential biological pathways, which could advance the identification of environmental risk factors of CP in early life.
摘要：
■空气污染与大脑结构变化有关，神经发生的中断，和神经发育障碍。产前暴露于环境空气污染与脑瘫（CP）风险之间的关系，这是儿童时期最常见的运动障碍，还没有被彻底调查。
■为了评估安大略省人口队列中出生的足月妊娠儿童的产前居住暴露于环境空气污染与CP风险之间的关联，加拿大。
■安大略省基于人群的队列研究，加拿大使用链接，全省卫生行政数据库。参与者是2002年4月1日至2017年3月31日在安大略省医院出生的单胎足月分娩（≥37孕周）。数据从2022年1月至12月进行了分析。
■直径为2.5μm（PM2.5）或更小的环境细颗粒物的周平均浓度，二氧化氮(NO2),根据基于卫星的估计和地面监测数据，由分娩时报告的产妇居住地分配的怀孕期间的臭氧（O3）。
■对于从出生到18岁的儿童，通过单一住院诊断或至少2次门诊诊断来确定CP病例。
■本研究包括1587935对达到足月妊娠的母子，其中3170名（0.2%）儿童被诊断为CP。研究人群的平均（SD）母亲年龄为30.1（5.6）岁，男性为811745名婴儿（51.1％）。产前环境PM2.5浓度的每IQR增加（2.7μg/m3）与CP的累积风险比（CHR）为1.12（95％CI，1.03-1.21）相关。男性婴儿的CHR（1.14;95％CI，1.02-1.26）高于女性婴儿的CHR（1.08;95％CI，0.96-1.22）。在研究人群中，未发现产前PM2.5暴露和CP的特定易感性窗口。未发现产前NO2或O3暴露和CP风险的关联或易感性窗口。
■在这项加拿大单胎足月出生的大型队列研究中，产前环境PM2.5暴露与后代CP风险增加相关.需要进一步的研究来探索这种关联及其潜在的生物学途径，这可以促进对生命早期CP环境危险因素的识别。
■为了评估安大略省人口队列中出生的足月妊娠儿童的产前居住暴露于环境空气污染与CP风险之间的关联，加拿大。
■安大略省基于人群的队列研究，加拿大使用链接，全省卫生行政数据库。参与者是2002年4月1日至2017年3月31日在安大略省医院出生的单胎足月分娩（≥37孕周）。数据从2022年1月至12月进行了分析。
■直径为2.5μm（PM2.5）或更小的环境细颗粒物的周平均浓度，二氧化氮(NO2),根据基于卫星的估计和地面监测数据，由分娩时报告的产妇居住地分配的怀孕期间的臭氧（O3）。
■对于从出生到18岁的儿童，通过单一住院诊断或至少2次门诊诊断来确定CP病例。
■本研究包括1587935对达到足月妊娠的母子，其中3170名（0.2%）儿童被诊断为CP。研究人群的平均（SD）母亲年龄为30.1（5.6）岁，男性为811745名婴儿（51.1％）。产前环境PM2.5浓度的每IQR增加（2.7μg/m3）与CP的累积风险比（CHR）为1.12（95％CI，1.03-1.21）相关。男性婴儿的CHR（1.14;95％CI，1.02-1.26）高于女性婴儿的CHR（1.08;95％CI，0.96-1.22）。在研究人群中，未发现产前PM2.5暴露和CP的特定易感性窗口。未发现产前NO2或O3暴露和CP风险的关联或易感性窗口。
■在这项加拿大单胎足月出生的大型队列研究中，产前环境PM2.5暴露与后代CP风险增加相关.需要进一步的研究来探索这种关联及其潜在的生物学途径，这可以促进对生命早期CP环境危险因素的识别。
