PDF(Pubmed)
Abstract：
UNASSIGNED: To compare rates of retinal nerve fiber layer change over time in healthy, eyes with nonprogressing glaucoma and eyes with progressing glaucoma using single wide-field (SWF) and optic nerve head (ONH) cube scan optical coherence tomography (OCT) images.
UNASSIGNED: Forty-five eyes of 25 healthy individuals and 263 eyes of 161 glaucoma patients from the Diagnostic Innovations in Glaucoma Study were included. All eyes underwent 24-2 visual field testing and OCT (Spectralis SD-OCT) ONH and macular imaging. SWF images (up to 43° × 28°) were created by stitching together ONH cube scans centered on the optic disc and macular cube scans centered on the fovea. Visual field progression was defined as guided progression analysis likely progression and/or a significant (P < 0.01) mean deviation slope of less than -1.0 dB/year. Mixed effects models were used to compare rates of change. Highly myopic eyes were included.
UNASSIGNED: Thirty glaucomatous eyes were classified as progressing. In eyes with glaucoma, mean global rate of change was -1.22 µm/year (P < 0.001) using SWF images and -0.83 µm/year (P = 0.003) using ONH cube scans. Rate of change was significantly greater in eyes with progressing glaucoma compared with eyes with nonprogressing glaucoma (-1.51 µm/year vs. -1.24 µm/year; P = 0.002) using SWF images and was similar using ONH cube scans (P = 0.27).
UNASSIGNED: In this cohort that includes eyes with and without high axial myopia, the mean rate of retinal nerve fiber layer thinning measured using SWF images was faster in eyes with progressing glaucoma than in eyes with nonprogressing glaucoma. Wide-field OCT images including the ONH and macula can be effective for monitoring glaucomatous progression in patients with and without high myopia.
UNASSIGNED: Forty-five eyes of 25 healthy individuals and 263 eyes of 161 glaucoma patients from the Diagnostic Innovations in Glaucoma Study were included. All eyes underwent 24-2 visual field testing and OCT (Spectralis SD-OCT) ONH and macular imaging. SWF images (up to 43° × 28°) were created by stitching together ONH cube scans centered on the optic disc and macular cube scans centered on the fovea. Visual field progression was defined as guided progression analysis likely progression and/or a significant (P < 0.01) mean deviation slope of less than -1.0 dB/year. Mixed effects models were used to compare rates of change. Highly myopic eyes were included.
UNASSIGNED: Thirty glaucomatous eyes were classified as progressing. In eyes with glaucoma, mean global rate of change was -1.22 µm/year (P < 0.001) using SWF images and -0.83 µm/year (P = 0.003) using ONH cube scans. Rate of change was significantly greater in eyes with progressing glaucoma compared with eyes with nonprogressing glaucoma (-1.51 µm/year vs. -1.24 µm/year; P = 0.002) using SWF images and was similar using ONH cube scans (P = 0.27).
UNASSIGNED: In this cohort that includes eyes with and without high axial myopia, the mean rate of retinal nerve fiber layer thinning measured using SWF images was faster in eyes with progressing glaucoma than in eyes with nonprogressing glaucoma. Wide-field OCT images including the ONH and macula can be effective for monitoring glaucomatous progression in patients with and without high myopia.
摘要：
■为了比较健康人群视网膜神经纤维层随时间变化的比率，使用单宽视野（SWF）和视神经头（ONH）立方体扫描光学相干断层扫描（OCT）图像，患有非进行性青光眼的眼睛和患有进行性青光眼的眼睛。
■纳入了来自青光眼诊断创新研究的25名健康个体的45只眼和161名青光眼患者的263只眼。所有眼睛均接受24-2视野测试和OCT（光谱SD-OCT）ONH和黄斑成像。通过将以视神经盘为中心的ONH立方体扫描和以中央凹为中心的黄斑立方体扫描拼接在一起来创建SWF图像(高达43°×28°)。视野进展定义为引导进展分析可能进展和/或小于-1.0dB/年的显著(P<0.01)平均偏差斜率。混合效应模型用于比较变化率。包括高度近视的眼睛。
■30只青光眼被分类为进展。在患有青光眼的眼睛中，使用SWF图像,平均全球变化率为-1.22µm/年(P<0.001),使用ONH立方体扫描,平均全球变化率为-0.83µm/年(P=0.003).与未进展性青光眼的眼睛相比，进展性青光眼的眼睛的变化率显着更高（-1.51µm/年与-1.24µm/年；P=0.002）使用SWF图像，使用ONH立方体扫描相似（P=0.27）。
■在这个群体中，包括有和没有高度轴性近视的眼睛，使用SWF图像测量的视网膜神经纤维层变薄的平均速率在进展性青光眼的眼中比在非进展性青光眼的眼中更快.包括ONH和黄斑的广角OCT图像可以有效地监测有和没有高度近视的患者的青光眼进展。
■纳入了来自青光眼诊断创新研究的25名健康个体的45只眼和161名青光眼患者的263只眼。所有眼睛均接受24-2视野测试和OCT（光谱SD-OCT）ONH和黄斑成像。通过将以视神经盘为中心的ONH立方体扫描和以中央凹为中心的黄斑立方体扫描拼接在一起来创建SWF图像(高达43°×28°)。视野进展定义为引导进展分析可能进展和/或小于-1.0dB/年的显著(P<0.01)平均偏差斜率。混合效应模型用于比较变化率。包括高度近视的眼睛。
■30只青光眼被分类为进展。在患有青光眼的眼睛中，使用SWF图像,平均全球变化率为-1.22µm/年(P<0.001),使用ONH立方体扫描,平均全球变化率为-0.83µm/年(P=0.003).与未进展性青光眼的眼睛相比，进展性青光眼的眼睛的变化率显着更高（-1.51µm/年与-1.24µm/年；P=0.002）使用SWF图像，使用ONH立方体扫描相似（P=0.27）。
■在这个群体中，包括有和没有高度轴性近视的眼睛，使用SWF图像测量的视网膜神经纤维层变薄的平均速率在进展性青光眼的眼中比在非进展性青光眼的眼中更快.包括ONH和黄斑的广角OCT图像可以有效地监测有和没有高度近视的患者的青光眼进展。
