Abstract：
A new polyketide, mauritone A (1) with six known polyketides curvulone B (2), curvularin (3), 12-oxocurvularin (4), (10E,15S)-10,11-dehydrocurvularin (5), (11R,15S)-11-hydroxycurvularin (6), and (11S,15S)-11-hydroxycurvularin (7) were isolated from the fungal-bacterial symbiont Aspergillus spelaeus GXIMD 04541/Sphingomonas echinoides GXIMD 04532 derived from Mauritia arabica. Their structures were elucidated by extensive spectral analysis. All compounds (1-7) were evaluated for their anti-inflammatory effects. The inhibitory effects of 4, 5, and 7 on nitric oxide (NO) production were found to be significant, with IC50 values of 5.5 ± 0.26, 2.0 ± 0.31, and 8.3 ± 0.62 μM, respectively, surpassing that of the positive control quercetin (10.6 ± 0.64 μM). Compounds 3 and 6 exhibited moderate inhibition of NO, with IC50 values of 18.6 ± 0.53 and 12.7 ± 0.45 μM, respectively.
摘要：
一种新的聚酮化合物,mauritoneA（1）与六个已知的聚酮CurvuloneB（2），Curvularin（3），12-氧孢素（4），(10E,15S)-10,11-脱氢curvularin(5)，(11R,15S)-11-羟基弯管素(6)，和（11S，15S）-11-羟基curvularin（7）是从源自毛里求斯的真菌-细菌共生体Spelaaeus曲霉GXIMD04541/鞘氨醇单胞菌GXIMD04532中分离出来的。通过广泛的光谱分析阐明了它们的结构。评价所有化合物(1-7)的抗炎作用。发现4、5和7对一氧化氮（NO）产生的抑制作用是显着的，IC50值为5.5±0.26、2.0±0.31和8.3±0.62μM，分别,超过阳性对照槲皮素（10.6±0.64μM）。化合物3和6表现出中度的NO抑制,IC50值为18.6±0.53和12.7±0.45μM，分别。
