{Reference Type}: Journal Article
{Title}: Mauritone A, a new polyketide from a fungal-bacterial symbiont Aspergillus spelaeus GXIMD 04541/Sphingomonas echinoides GXIMD 04532.
{Author}: Yang J;Yao FH;Xu SF;Shi JY;Li XY;Yi XX;Gao CH;
{Journal}: Nat Prod Res
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jul 9
{Factor}: 2.488
{DOI}: 10.1080/14786419.2024.2377313
{Abstract}: A new polyketide, mauritone A (1) with six known polyketides curvulone B (2), curvularin (3), 12-oxocurvularin (4), (10E,15S)-10,11-dehydrocurvularin (5), (11R,15S)-11-hydroxycurvularin (6), and (11S,15S)-11-hydroxycurvularin (7) were isolated from the fungal-bacterial symbiont Aspergillus spelaeus GXIMD 04541/Sphingomonas echinoides GXIMD 04532 derived from Mauritia arabica. Their structures were elucidated by extensive spectral analysis. All compounds (1-7) were evaluated for their anti-inflammatory effects. The inhibitory effects of 4, 5, and 7 on nitric oxide (NO) production were found to be significant, with IC50 values of 5.5 ± 0.26, 2.0 ± 0.31, and 8.3 ± 0.62 μM, respectively, surpassing that of the positive control quercetin (10.6 ± 0.64 μM). Compounds 3 and 6 exhibited moderate inhibition of NO, with IC50 values of 18.6 ± 0.53 and 12.7 ± 0.45 μM, respectively.