Abstract：
BACKGROUND: Folic acid (FA), a synthetically produced compound analogous to vitamin B9, also referred to as vitamin folate, is an essential compound in human health and faces challenges in stability during food processing. This study explores the incorporation of FA into carboxymethylcellulose (CMC) nanofibers using electrospinning to enhance its stability.
RESULTS: In this study, optimization of both electrospinning and solution parameters facilitated the fabrication of nanofibers. Furthermore, incorporating FA into CMC/polyethylene oxide (PEO) nanofibers resulted in thinner fibers, with an average diameter of 88 nm, characterized by a flat shape and smooth surface. Fourier transform infrared spectroscopic analysis demonstrated substantial hydrogen bonding interactions between FA and the polar groups present in CMC. This interaction contributed to an encapsulation efficiency of 94.5%, with a yield exceeding 87%. Thermal analysis highlighted mutual interference between CMC and PEO, with FA enhancing the thermal stability and reducing the melting temperatures and enthalpies of PEO, while also increasing the reaction heats of CMC. The encapsulated FA remained stable in acidic conditions, with only 6% degradation over 30 days, demonstrating the efficacy of CMC/PEO nanofibers in safeguarding FA against acidic environments. Moreover, the nanofibers provided a protective barrier against UV radiation, thereby preserving the stability of FA.
CONCLUSIONS: This study emphasizes the efficacy of CMC/PEO nanofibers as a protective matrix against FA degradation. The findings indicate that this innovative approach could significantly diversify the applications of FA in food fortification, addressing concerns regarding its vulnerability to temperature and hydrolysis reactions during food processing. © 2024 Society of Chemical Industry.
RESULTS: In this study, optimization of both electrospinning and solution parameters facilitated the fabrication of nanofibers. Furthermore, incorporating FA into CMC/polyethylene oxide (PEO) nanofibers resulted in thinner fibers, with an average diameter of 88 nm, characterized by a flat shape and smooth surface. Fourier transform infrared spectroscopic analysis demonstrated substantial hydrogen bonding interactions between FA and the polar groups present in CMC. This interaction contributed to an encapsulation efficiency of 94.5%, with a yield exceeding 87%. Thermal analysis highlighted mutual interference between CMC and PEO, with FA enhancing the thermal stability and reducing the melting temperatures and enthalpies of PEO, while also increasing the reaction heats of CMC. The encapsulated FA remained stable in acidic conditions, with only 6% degradation over 30 days, demonstrating the efficacy of CMC/PEO nanofibers in safeguarding FA against acidic environments. Moreover, the nanofibers provided a protective barrier against UV radiation, thereby preserving the stability of FA.
CONCLUSIONS: This study emphasizes the efficacy of CMC/PEO nanofibers as a protective matrix against FA degradation. The findings indicate that this innovative approach could significantly diversify the applications of FA in food fortification, addressing concerns regarding its vulnerability to temperature and hydrolysis reactions during food processing. © 2024 Society of Chemical Industry.
摘要：
背景：叶酸（FA），一种类似于维生素B9的合成化合物，也称为维生素叶酸，是人类健康中必不可少的化合物，在食品加工过程中面临稳定性挑战。这项研究探索了使用静电纺丝将FA掺入羧甲基纤维素（CMC）纳米纤维中以增强其稳定性。
结果：在这项研究中，静电纺丝和溶液参数的优化促进了纳米纤维的制备。此外，将FA掺入CMC/聚环氧乙烷（PEO）纳米纤维中，导致纤维更细，平均直径为88nm,其特点是一个平坦的形状和光滑的表面。傅里叶变换红外光谱分析显示FA与CMC中存在的极性基团之间的大量氢键相互作用。这种相互作用有助于94.5%的封装效率，收益率超过87%。热分析强调了CMC和PEO之间的相互干扰，FA提高了热稳定性，降低了PEO的熔化温度和焓，同时也增加了CMC的反应热。封装的FA在酸性条件下保持稳定，在30天内只有6%的降解，证明CMC/PEO纳米纤维在保护FA免受酸性环境中的功效。此外，纳米纤维提供了对紫外线辐射的保护屏障，从而保持FA的稳定性。
结论：本研究强调了CMC/PEO纳米纤维作为针对FA降解的保护性基质的功效。研究结果表明，这种创新的方法可以显着多样化FA在食品强化中的应用，解决有关其在食品加工过程中对温度和水解反应的脆弱性的担忧。©2024化学工业学会。
结果：在这项研究中，静电纺丝和溶液参数的优化促进了纳米纤维的制备。此外，将FA掺入CMC/聚环氧乙烷（PEO）纳米纤维中，导致纤维更细，平均直径为88nm,其特点是一个平坦的形状和光滑的表面。傅里叶变换红外光谱分析显示FA与CMC中存在的极性基团之间的大量氢键相互作用。这种相互作用有助于94.5%的封装效率，收益率超过87%。热分析强调了CMC和PEO之间的相互干扰，FA提高了热稳定性，降低了PEO的熔化温度和焓，同时也增加了CMC的反应热。封装的FA在酸性条件下保持稳定，在30天内只有6%的降解，证明CMC/PEO纳米纤维在保护FA免受酸性环境中的功效。此外，纳米纤维提供了对紫外线辐射的保护屏障，从而保持FA的稳定性。
结论：本研究强调了CMC/PEO纳米纤维作为针对FA降解的保护性基质的功效。研究结果表明，这种创新的方法可以显着多样化FA在食品强化中的应用，解决有关其在食品加工过程中对温度和水解反应的脆弱性的担忧。©2024化学工业学会。
