关键词: ear’s melanoma external auditory canal melanoma skull base surgery surgery for melanoma

Mesh : Humans Ear Canal / pathology surgery Ear Neoplasms / pathology surgery Melanoma / pathology surgery diagnosis Prognosis Sentinel Lymph Node Biopsy

来  源:   DOI:10.32074/1591-951X-980

Abstract:
Melanoma of the external auditory canal (EAC) is particularly rare and poorly understood, with limited available data on management and survival. This systematic review aims to analyze existing data and provide insights into the management and prognosis the beginning of EAC melanoma. It is conducted using Pubmed and Scopus databases from the beginning to July 2023 and it follows the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) 2020 guidelines. Searches are performed using the search string \"(melanoma) AND (external auditory canal)\".
The review includes a total of 30 patients diagnosed with EAC melanoma, supplemented by an additional case from the authors\' clinical experience. The role of Breslow thickness as a determining factor for the choice of surgery remains inconclusive due to limited available data. Sentinel lymph node biopsy and adjuvant therapy are sparingly employed, indicating the need for standardized guidelines. Patients in the study demonstrate a 50% overall survival rate at 5 years.
EAC Melanoma is a rare and aggressive malignancy with limited therapeutic guidelines. Surgical interventions, including wide local excision and lateral temporal bone resection, are the primary treatment options for patients without distant metastases.
摘要:
外耳道(EAC)的黑色素瘤特别罕见且知之甚少,关于管理和生存的可用数据有限。本系统综述旨在分析现有数据,并提供对EAC黑色素瘤开始时的管理和预后的见解。它从2023年7月开始使用Pubmed和Scopus数据库进行,并遵循2020年系统审查和荟萃分析(PRISMA)指南的首选报告项目。使用搜索字符串\"(黑色素瘤)AND(外耳道)\"进行搜索。
该综述共包括30名诊断为EAC黑色素瘤的患者,由作者的临床经验补充。由于可用数据有限,Breslow厚度作为选择手术的决定因素的作用仍不确定。前哨淋巴结活检和辅助治疗很少使用,表明需要标准化指南。研究中的患者在5年时表现出50%的总生存率。
EAC黑色素瘤是一种罕见的侵袭性恶性肿瘤,治疗指南有限。手术干预,包括广泛的局部切除和颞骨外侧切除,是无远处转移患者的主要治疗选择。
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