PDF(Pubmed)
Abstract：
Orthopedic infection is one of the most intractable orthopedic problems. Bacteria resistant to antibiotics also develop gradually. Chitosan is widely used in the Biomedical field because of its high biocompatibility, biodegradability, and antibacterial activity. Chitosan-based drug delivery systems are frequently utilized to produce controlled medication release. When combined with antibiotics, synergistic antibacterial effects can be achieved. Chitosan-based nanoparticles are one of the most widely used applications in drug delivery systems. The focus of this review is to provide information on new methods being developed for chitosan-based nanoparticles in the field of bone infection treatment, including chitosan nanoparticles for antibacterial purposes, Ch-loaded with antibiotics, Ch-loaded with metal, and used as immune adjuvants. It may Provide ideas for the fundamental research and the prospects of future clinical applications of orthopedic infections.
摘要：
骨科感染是最棘手的骨科问题之一。对抗生素耐药的细菌也逐渐发展。壳聚糖由于具有较高的生物相容性,在生物医学领域得到了广泛的应用,生物降解性，和抗菌活性。基于壳聚糖的药物递送系统经常用于产生受控的药物释放。当与抗生素联合使用时，可以实现协同抗菌效果。基于壳聚糖的纳米颗粒是药物递送系统中最广泛使用的应用之一。这篇综述的重点是提供有关正在开发的基于壳聚糖的纳米颗粒在骨感染治疗领域的新方法的信息。包括用于抗菌目的的壳聚糖纳米颗粒，装满抗生素，装有金属，用作免疫佐剂。为骨科感染的基础研究和未来临床应用提供思路。
