PDF(Pubmed)
Abstract：
Colorectal cancer (CRC) is a common type of gastrointestinal tract (GIT) cancer and poses an enormous threat to human health. Current strategies for metastatic colorectal cancer (mCRC) therapy primarily focus on chemotherapy, targeted therapy, immunotherapy, and radiotherapy; however, their adverse reactions and drug resistance limit their clinical application. Advances in nanotechnology have rendered lipid nanoparticles (LNPs) a promising nanomaterial-based drug delivery system for CRC therapy. LNPs can adapt to the biological characteristics of CRC by modifying their formulation, enabling the selective delivery of drugs to cancer tissues. They overcome the limitations of traditional therapies, such as poor water solubility, nonspecific biodistribution, and limited bioavailability. Herein, we review the composition and targeting strategies of LNPs for CRC therapy. Subsequently, the applications of these nanoparticles in CRC treatment including drug delivery, thermal therapy, and nucleic acid-based gene therapy are summarized with examples provided. The last section provides a glimpse into the advantages, current limitations, and prospects of LNPs in the treatment of CRC.
摘要：
结直肠癌(CRC)是一种常见的胃肠道(GIT)癌症,对人类健康构成巨大威胁。目前转移性结直肠癌（mCRC）治疗策略主要集中在化疗，靶向治疗,免疫疗法，和放射治疗；然而，其不良反应和耐药性限制了其临床应用。纳米技术的进步使脂质纳米颗粒（LNP）成为一种有前途的基于纳米材料的CRC治疗药物递送系统。LNPs可以通过修改其配方来适应CRC的生物学特性，能够选择性地将药物输送到癌症组织。他们克服了传统疗法的局限性，如水溶性差，非特异性生物分布，和有限的生物利用度。在这里，我们综述了用于CRC治疗的LNP的组成和靶向策略.随后，这些纳米颗粒在CRC治疗中的应用，包括药物递送，热疗,总结了基于核酸的基因治疗，并提供了实例。最后一部分提供了对优点的一瞥，电流限制，以及LNPs在CRC治疗中的前景。
